(alphaS)-alpha-[[(tert-Butoxy)carbonyl]amino]-5-pyrimidinepropanoic acid

Base Information

• Chemical Name: (alphaS)-alpha-[[(tert-Butoxy)carbonyl]amino]-5-pyrimidinepropanoic acid
• CAS No.: 1251904-63-8
• Molecular Formula: C12H17N3O4
• Molecular Weight: 267.28
• Mol file: 1251904-63-8.mol

Synonyms:Boc-3-(5-Pyrimidinyl)-L-Alanine;(S)-2-((tert-Butoxycarbonyl)amino)-3-(pyrimidin-5-yl)propanoic acid;(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-(pyrimidin-5-yl)propanoic acid;(alphaS)-alpha-[[(tert-Butoxy)carbonyl]amino]-5-pyrimidinepropanoic acid

Chemical Property of (alphaS)-alpha-[[(tert-Butoxy)carbonyl]amino]-5-pyrimidinepropanoic acid

Chemical Property:

• PSA: 104.90000
• Density: 1.242
• LogP: 1.20140

Purity/Quality:

98%min ^*data from raw suppliers

(2S)-2-([(TERT-BUTOXY)CARBONYL]AMINO)-3-(PYRIMIDIN-5-YL)PROPANOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (alphaS)-alpha-[[(tert-Butoxy)carbonyl]amino]-5-pyrimidinepropanoic acid

There total 2 articles about (alphaS)-alpha-[[(tert-Butoxy)carbonyl]amino]-5-pyrimidinepropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-methyl 2-((tert-butoxycarbonyl) amino)-3-(pyrimidin-5-yl)propanoate (1006587-30-9) → (S)-2-((tert-butoxycarbonyl) amino)-3-(pyrimidin-5-yl)propanoic acid (1251904-63-8,1354970-54-9)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at 25 ℃; for 2h;

Reference yield:

N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester (93267-04-0,170848-34-7,889670-02-4) → (S)-2-((tert-butoxycarbonyl) amino)-3-(pyrimidin-5-yl)propanoic acid (1251904-63-8,1354970-54-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: zinc; tertiary butyl chloride / N,N-dimethyl-formamide / 0.5 h

1.2: 16 h / 50 °C / Inert atmosphere

2.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 2 h / 25 °C

With lithium hydroxide monohydrate; tertiary butyl chloride; zinc; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

upstream raw materials:

N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester

(S)-methyl 2-((tert-butoxycarbonyl) amino)-3-(pyrimidin-5-yl)propanoate

Refernces