3'-Nitro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-carboxylic acid, 98+% C11H13N3O4, MW: 251.24

Base Information

• Chemical Name: 3'-Nitro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-carboxylic acid, 98+% C11H13N3O4, MW: 251.24
• CAS No.: 758720-54-6
• Molecular Formula: C₁₁H₁₃N₃O₄
• Molecular Weight: 251.242
• Hs Code.: 2933990090
• Mol file: 758720-54-6.mol

Synonyms:3-Nitro-benzolsulfonsaeure-piperidid;

Chemical Property of 3'-Nitro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-carboxylic acid, 98+% C11H13N3O4, MW: 251.24

Chemical Property:

• PSA: 99.25000
• Density: 1.121
• LogP: 1.87900

Purity/Quality:

98%min ^*data from raw suppliers

1-(3-Nitropyridin-2-yl)piperidine-4-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3'-Nitro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-carboxylic acid, 98+% C11H13N3O4, MW: 251.24

There total 3 articles about 3'-Nitro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-carboxylic acid, 98+% C11H13N3O4, MW: 251.24 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

isonipecotic acid (498-94-2) + 2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) → 1-(3-nitropyridin-2-yl)piperidine-4-carboxylic acid (758720-54-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 1.5h; Microwave irradiation; Inert atmosphere;

DOI:10.1016/j.bmcl.2018.05.017

Reference yield:

Ethyl 1-(3-nitropyridin-2-yl)piperidine-4-carboxylate (955396-99-3) → 1-(3-nitropyridin-2-yl)piperidine-4-carboxylic acid (758720-54-6)

Guidance literature:

Ethyl 1-(3-nitropyridin-2-yl)piperidine-4-carboxylate; With potassium hydroxide; water; In methanol; at 20 ℃; for 1.5h;

With hydrogenchloride; In methanol; water;

Reference yield:

→ 1-(3-nitropyridin-2-yl)piperidine-4-carboxylic acid (758720-54-6)

Guidance literature:

upstream raw materials:

isonipecotic acid

2-Chloro-3-nitropyridine

Ethyl 1-(3-nitropyridin-2-yl)piperidine-4-carboxylate

Refernces

• 1、 -. "NOVEL HETEROCYCLIC DERIVATIVES AS M-GLU5 ANTAGONISTS". Page/Page column 75. . Retrieved 2009/03/07.
• 2、 -. "Substituted benzoylureidopyridylpiperidine-and-pyrrolidinecarboxylic acid derivatives, processes for preparing them and their use". Page 7. . Retrieved 2008/06/13.