2-Amino-5-methylphenol

Base Information

• Chemical Name: 2-Amino-5-methylphenol
• CAS No.: 2835-98-5
• Molecular Formula: C7H9NO
• Molecular Weight: 123.155
• Hs Code.: 2922.29
• European Community (EC) Number: 220-620-7
• NSC Number: 322874
• UNII: QCG4ES2A26
• DSSTox Substance ID: DTXSID20182594
• Nikkaji Number: J13.777D
• Wikidata: Q27287198
• Mol file: 2835-98-5.mol

Synonyms:2-amino-5-methylphenol;6-amino-m-cresol

Chemical Property of 2-Amino-5-methylphenol

Chemical Property:

• Appearance/Colour: Beige to brown crystal powder
• Melting Point: 160-162 °C(lit.)
• Refractive Index: 1.5380 (estimate)
• Boiling Point: 241.4 °C at 760 mmHg
• PKA: 9.87±0.10(Predicted)
• Flash Point: 99.8 °C
• PSA: 46.25000
• Density: 1.157 g/cm³
• LogP: 1.86400
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Water Solubility.: soluble
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 123.068413911
• Heavy Atom Count: 9
• Complexity: 94.9

Purity/Quality:

98%, ^*data from raw suppliers

2-Amino-5-methylphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1)N)O
• Uses: 2-Amino-5-methylphenol was used in the synthesis of tridentate Schiff base ligand and novel non-metallocene catalysts with phenoxy-imine ligands.

Technology Process of 2-Amino-5-methylphenol

There total 12 articles about 2-Amino-5-methylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-nitro-5-methylphenol (700-38-9) → 2-Hydroxy-4-methylanilin (2835-98-5)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 23 ℃; for 5h;

Reference yield: 98.0%

→ 2-Hydroxy-4-methylanilin (2835-98-5)

Guidance literature:

Reference yield:

2-Amino-5-methylbenzenesulfonic acid (88-44-8) → 2-Hydroxy-4-methylanilin (2835-98-5)

Guidance literature:

upstream raw materials:

2-nitro-5-methylphenol

O-(3-methylphenyl)hydroxylamine

(1R,5S,8R)-8-methoxy-3,3-dimethyl-2,4,7-trioxabicyclo[3.3.0]octan-6-one

benzylamine

Downstream raw materials:

N-(2-hydroxy-4-methylphenyl)furan-2-carboxamide

N-(2-hydroxy-4-methylphenyl)acetamide

5-(2-hydroxy-4-methyl-phenylcarbamoyl)-benzene-1,3-disulfonyl chloride

2-(4-tert-pentyl-phenoxy)-butyric acid-(2-hydroxy-4-methyl-anilide)