ABCB1

Base Information

• Chemical Name: ABCB1
• CAS No.: 292171-04-1
• Molecular Formula: C14H21N3O5
• Molecular Weight: 311.336
• Mol file: 292171-04-1.mol

Synonyms:ABCB1;MDR1 HUMAN MEMBRANE PREPARATION;PGP;Ac-Pro-Gly-Pro-OH;AcPGP;1-Acetyl-L-prolylglycyl-L-proline;Acetyl Pro-Gly-Pro;Acetyl-proline-glycine-proline

Chemical Property of ABCB1

Chemical Property:

• PSA: 107.02000
• LogP: -0.54420
• Storage Temp.: ?20°C
• Solubility.: deionized water: ≥2mg/mL

Purity/Quality:

99%, ^*data from raw suppliers

Abcb1 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ABCB1

There total 4 articles about ABCB1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Ac-L-Pro-Gly-L-Pro-OtBu → N-acetyl-PGP (292171-04-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

(S)-tert-butyl 1-(2-(((benzyloxy)carbonyl)amino)acetyl)pyrrolidine-2-carboxylate (24277-16-5) → N-acetyl-PGP (292171-04-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 5%-palladium/activated carbon; hydrogen / methanol / 1 h

2.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.25 h / -15 °C

2.2: 1 h

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With 4-methyl-morpholine; 5%-palladium/activated carbon; hydrogen; trifluoroacetic acid; isobutyl chloroformate; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

glycylproline tert-butyl ester (60166-68-9) → N-acetyl-PGP (292171-04-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.25 h / -15 °C

1.2: 1 h

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With 4-methyl-morpholine; trifluoroacetic acid; isobutyl chloroformate; In tetrahydrofuran; dichloromethane;

upstream raw materials:

(S)-tert-butyl 1-(2-(((benzyloxy)carbonyl)amino)acetyl)pyrrolidine-2-carboxylate

glycylproline tert-butyl ester

L-proline tert-butyl ester hydrochloride