trans-4-(tert-butoxycarbonylamino)cyclohexyl 4-methylbenzenesulfonate

Base Information

• Chemical Name: trans-4-(tert-butoxycarbonylamino)cyclohexyl 4-methylbenzenesulfonate
• CAS No.: 957035-42-6
• Molecular Formula: C18H27NO5S
• Molecular Weight: 369.48
• Hs Code.: 2924299090
• Mol file: 957035-42-6.mol

Synonyms:trans-4-(BOC-amino)cyclohexyl tosylate;trans-4-(tert-butoxycarbonylamino)cyclohexyl 4-methylbenzenesulfonate;N-[trans-4-[[(4-Methylphenyl)sulfonyl]oxy]cyclohexyl]carbamic acid 1,1-dimethylethyl ester

Chemical Property of trans-4-(tert-butoxycarbonylamino)cyclohexyl 4-methylbenzenesulfonate

Chemical Property:

• Vapor Pressure: 1.49E-10mmHg at 25°C
• Boiling Point: 510.9°C at 760 mmHg
• Flash Point: 262.8°C
• PSA: 90.08000
• Density: 1.21g/cm³
• LogP: 5.00790
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

trans-4-((tert-Butoxycarbonyl)amino)cyclohexyl4-Methylbenzenesulfonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of trans-4-(tert-butoxycarbonylamino)cyclohexyl 4-methylbenzenesulfonate

There total 2 articles about trans-4-(tert-butoxycarbonylamino)cyclohexyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-toluenesulfonyl chloride (98-59-9) + trans-tert-butyl 4-hydroxycyclohexylcarbamate (111300-06-2) → trans-4-[(tert-butoxycarbonyl)amino]cyclohexyl 4-methylbenzenesulfonate (957035-42-6,1017241-31-4)

Guidance literature:

With pyridine; dmap; at 20 ℃;

DOI:10.1016/j.bmcl.2018.07.042

Reference yield:

→ trans-4-[(tert-butoxycarbonyl)amino]cyclohexyl 4-methylbenzenesulfonate (957035-42-6,1017241-31-4)

Guidance literature:

Reference yield:

4-(3-chloro-2-fluoroanilino)-6-hydroxy-7-methoxyquinazoline (612501-52-7) + trans-4-[(tert-butoxycarbonyl)amino]cyclohexyl 4-methylbenzenesulfonate (957035-42-6,1017241-31-4) → 4-[(3-chloro-2-fluoro-phenyl)amino]-6-[cis-4-(tert-butoxycarbonyl-amino)-cyclohexyl-oxy]-7-methoxy-quinazoline (1024014-97-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃;

upstream raw materials:

p-toluenesulfonyl chloride

trans-tert-butyl 4-hydroxycyclohexylcarbamate

Downstream raw materials:

4-[(3-chloro-2-fluoro-phenyl)amino]-6-[cis-4-(tert-butoxycarbonyl-amino)-cyclohexyl-oxy]-7-methoxy-quinazoline

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