3-acetaMido-4-(2,3-dihydroxypropyl)naphthalen-1-yl tert-butyl carbonate

Base Information

• Chemical Name: 3-acetaMido-4-(2,3-dihydroxypropyl)naphthalen-1-yl tert-butyl carbonate
• CAS No.: 144191-95-7
• Molecular Formula: C20H25NO6
• Molecular Weight: 375.4156
• Mol file: 144191-95-7.mol

Synonyms:Carbonic acid 3-acetylamino-4-(2,3-dihydroxy-propyl)-naphthalen-1-yl ester tert-butyl ester;

Chemical Property of 3-acetaMido-4-(2,3-dihydroxypropyl)naphthalen-1-yl tert-butyl carbonate

Chemical Property:

• PSA: 105.09000
• LogP: 3.08080

Purity/Quality:

3-acetamido-4-(2,3-dihydroxypropyl)naphthalen-1-yltert-butylcarbonate 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-acetaMido-4-(2,3-dihydroxypropyl)naphthalen-1-yl tert-butyl carbonate

There total 7 articles about 3-acetaMido-4-(2,3-dihydroxypropyl)naphthalen-1-yl tert-butyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 1,2-dihydroxy-3-<2-(aminoacetyl)-4-<<(tert-butyloxy)carbonyl>oxy>naphthalen-1-yl>propane (144191-95-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) 4-dimethylaminopyridine, 2) Na₂S₂O₄ / 1) CH₃CN, 18 h, RT, 2) H₂O, EtOAc, 24 h, RT

2: 84 percent / N-methylmorpholine N-oxide, OsO₄ / acetone; H₂O / 18 h / Ambient temperature

3: formic acid / 10percent Pd-C / methanol / 0.5 h / Ambient temperature

4: pyridine / 1 h

With pyridine; dmap; osmium(VIII) oxide; formic acid; sodium dithionite; 4-methylmorpholine N-oxide; palladium on activated charcoal; In methanol; water; acetone;

DOI:10.1021/jo00049a035

Reference yield:

2-benzylamino-[1,4]naphthoquinone (24137-17-5) → 1,2-dihydroxy-3-<2-(aminoacetyl)-4-<<(tert-butyloxy)carbonyl>oxy>naphthalen-1-yl>propane (144191-95-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 75 percent / tetrahydrofuran; diethyl ether / 1 h / 5 °C

2: 1) 4-dimethylaminopyridine, 2) Na₂S₂O₄ / 1) CH₃CN, 18 h, RT, 2) H₂O, EtOAc, 24 h, RT

3: 84 percent / N-methylmorpholine N-oxide, OsO₄ / acetone; H₂O / 18 h / Ambient temperature

4: formic acid / 10percent Pd-C / methanol / 0.5 h / Ambient temperature

5: pyridine / 1 h

With pyridine; dmap; osmium(VIII) oxide; formic acid; sodium dithionite; 4-methylmorpholine N-oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; water; acetone;

DOI:10.1021/jo00049a035

Reference yield:

1-hydroxy-1-allyl-2-(benzylamino)-1,4-dihydronaphthalen-4-one (143144-66-5) → 1,2-dihydroxy-3-<2-(aminoacetyl)-4-<<(tert-butyloxy)carbonyl>oxy>naphthalen-1-yl>propane (144191-95-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) 4-dimethylaminopyridine, 2) Na₂S₂O₄ / 1) CH₃CN, 18 h, RT, 2) H₂O, EtOAc, 24 h, RT

2: 84 percent / N-methylmorpholine N-oxide, OsO₄ / acetone; H₂O / 18 h / Ambient temperature

3: formic acid / 10percent Pd-C / methanol / 0.5 h / Ambient temperature

4: pyridine / 1 h

With pyridine; dmap; osmium(VIII) oxide; formic acid; sodium dithionite; 4-methylmorpholine N-oxide; palladium on activated charcoal; In methanol; water; acetone;

DOI:10.1021/jo00049a035

upstream raw materials:

acetic anhydride

di-tert-butyl dicarbonate

2-benzylamino-[1,4]naphthoquinone

1-hydroxy-1-allyl-2-(benzylamino)-1,4-dihydronaphthalen-4-one

Downstream raw materials:

1-<(methylsulfonyl)oxy>-2-hydroxy-3-<2-(benzylamino)-4-<<(tert-butyloxy)carbonyl>oxy>naphthalen-1-yl>propane

3-acetyl-2-hydroxy-5-<<(tert-butyloxy)carbonyl>oxy>-1,2,3,4-tetrahydro-4H-benzoquinoline

(2S)-3-acetyl-2-hydroxy-5-<<(tert-butyloxy)carbonyl>oxy>-1,2,3,4-tetrahydrobenzoquinoline, (R)-(-)-acetylmandelate ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 144191-95-7 3-acetaMido-4-(2,3-dihydroxypropyl)naphthalen-1-yl tert-butyl carbonate

Send

Send

Metric Ton KG G Pound L ML

Send

Send