2-Fluoro-5-methylbenzyl alcohol

Base Information

• Chemical Name: 2-Fluoro-5-methylbenzyl alcohol
• CAS No.: 64977-30-6
• Molecular Formula: C8H9FO
• Molecular Weight: 140.157
• Hs Code.: 2906299090
• European Community (EC) Number: 852-482-4
• DSSTox Substance ID: DTXSID00496843
• Wikidata: Q72474546
• Mol file: 64977-30-6.mol

Synonyms:2-Fluoro-5-methylbenzyl alcohol;64977-30-6;(2-fluoro-5-methylphenyl)methanol;(2-fluoro-5-methyl-phenyl)-methanol;SCHEMBL268243;2-Fluoro-5-methylbenzylalcohol;DTXSID00496843;2-Fluoro-5-methyl-benzyl alcohol;KJNSKKLMCXORGH-UHFFFAOYSA-N;Benzenemethanol, 2-fluoro-5-methyl-;CK2472;MFCD06202823;AKOS011800122;AS-45909;AM20040958;CS-0194189;EN300-245363;J-509455;Z992343034

Chemical Property of 2-Fluoro-5-methylbenzyl alcohol

Chemical Property:

• Boiling Point: 216℃
• Flash Point: 104℃
• PSA: 20.23000
• Density: 1.132
• LogP: 1.62640
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 140.063743068
• Heavy Atom Count: 10
• Complexity: 105

Purity/Quality:

98%Min ^*data from raw suppliers

2-Fluoro-5-methylbenzylAlcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C=C1)F)CO

Technology Process of 2-Fluoro-5-methylbenzyl alcohol

There total 2 articles about 2-Fluoro-5-methylbenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluoro-5-methyl-benzoic acid (321-12-0) → 2-fluoro-5-methyl-benzenemethanol (64977-30-6)

Guidance literature:

Multistep reaction; (i) LiAlH₄, Et₂O, (ii) AcOEt, (iii) aq. NaOH;

DOI:10.1021/jm00199a007

Reference yield:

3-bromo-4-fluorotoluene (452-62-0) → 2-fluoro-5-methyl-benzenemethanol (64977-30-6)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) nBuLi, Et₂O, (ii) /BRN= 1900390/

2: (i) LiAlH₄, Et₂O, (ii) AcOEt, (iii) aq. NaOH

DOI:10.1021/jm00199a007

Reference yield:

2-fluoro-5-methyl-benzenemethanol (64977-30-6) → 2-(bromomethyl)-1-fluoro-4-methylbenzene (886500-09-0)

Guidance literature:

With boron tribromide; at -45 - 20 ℃;

upstream raw materials:

2-fluoro-5-methyl-benzoic acid

3-bromo-4-fluorotoluene

Downstream raw materials:

2-Fluor-5-methylbenzylchlorid

2-(bromomethyl)-1-fluoro-4-methylbenzene