N-[4-[(2-Methoxyethyl)methylamino]phenyl]-2-phenyl-5-(trifluoromethyl)-4-oxazolecarboxamide

Base Information

Chemical Name:N-[4-[(2-Methoxyethyl)methylamino]phenyl]-2-phenyl-5-(trifluoromethyl)-4-oxazolecarboxamide
CAS No.:1231243-91-6
Molecular Formula:C₂₁H₂₀F₃N₃O₃
Molecular Weight:419.403
Hs Code.:2934999090
Mol file:1231243-91-6.mol

Synonyms:N-[4-[(2-Methoxyethyl)methylamino]phenyl]-2-phenyl-5-(trifluoromethyl)-4-oxazolecarboxamide;N-{4-[(2-Methoxyethyl)(Methyl)aMino]phenyl}-2-phenyl-5-(trifluoroMethyl)-1,3-oxazole-4-carboxaMide

Suppliers and Price of N-[4-[(2-Methoxyethyl)methylamino]phenyl]-2-phenyl-5-(trifluoromethyl)-4-oxazolecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
SCD1inhibitor >98%
250 mg
$ 1100.00

DC Chemicals
SCD1inhibitor >98%
100 mg
$ 600.00

Total 6 raw suppliers

Chemical Property of N-[4-[(2-Methoxyethyl)methylamino]phenyl]-2-phenyl-5-(trifluoromethyl)-4-oxazolecarboxamide

Chemical Property:

PKA:9.97±0.70(Predicted)
PSA：67.60000
Density:1.308±0.06 g/cm3(Predicted)
LogP:4.76830

Purity/Quality:

98%Min ^*data from raw suppliers

SCD1inhibitor >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-[4-[(2-Methoxyethyl)methylamino]phenyl]-2-phenyl-5-(trifluoromethyl)-4-oxazolecarboxamide

There total 2 articles about N-[4-[(2-Methoxyethyl)methylamino]phenyl]-2-phenyl-5-(trifluoromethyl)-4-oxazolecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1231243-91-6
2-phenyl-5-trifluoromethyloxazole-4-carboxylic acid {4-[(2-methoxyethyl)(methyl)amino]phenyl}amide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere

2: 5% Pd(II)/C(eggshell); hydrogen / tetrahydrofuran; methanol

3: triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / Inert atmosphere

With 5% Pd(II)/C(eggshell); hydrogen; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm101580m

Reference yield:

: 151951-34-7
N-(2-methoxyethyl)-N-methyl-4-nitroaniline

: 1231243-91-6
2-phenyl-5-trifluoromethyloxazole-4-carboxylic acid {4-[(2-methoxyethyl)(methyl)amino]phenyl}amide

Guidance literature:: Multi-step reaction with 2 steps

1: 5% Pd(II)/C(eggshell); hydrogen / tetrahydrofuran; methanol

2: triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / Inert atmosphere

With 5% Pd(II)/C(eggshell); hydrogen; triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm101580m