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Technology Process of α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile

α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile

Base Information
  • Chemical Name:α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
  • CAS No.:218136-59-5
  • Molecular Formula:C27H29N5
  • Molecular Weight:423.55
  • Hs Code.:
  • Mol file:218136-59-5.mol
α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile

Synonyms:SC 26196;α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile;alpha,alpha-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile;α,α-Diphenyl-4-[(3-pyridinylMethylene)aMino]-1-piperazine;2,2-diphenyl-5-{4-[(E)-(pyridin-3-ylMethylidene)aMino]piperazin-1-yl}pentanenitrile;PF-o6341724;(E)-2,2-diphenyl-5-(4-((pyridin-3-ylMethylene)aMino)piperazin-1-yl)pentanenitrile

Suppliers and Price of α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • SC-26196
  • 10mg
  • $ 418.00
  • TRC
  • SC-26196
  • 100mg
  • $ 1010.00
  • Tocris
  • SC26196 ≥98%(HPLC)
  • 50
  • $ 742.00
  • Tocris
  • SC26196 ≥98%(HPLC)
  • 10
  • $ 179.00
  • Sigma-Aldrich
  • SC-26196 ≥98% (HPLC)
  • 5mg
  • $ 122.00
  • Sigma-Aldrich
  • SC-26196 ≥98% (HPLC)
  • 25mg
  • $ 458.00
  • Medical Isotopes, Inc.
  • SC-26196
  • 100 mg
  • $ 1460.00
  • DC Chemicals
  • SC-26196 >98%
  • 1 g
  • $ 1900.00
  • DC Chemicals
  • SC-26196 >98%
  • 100 mg
  • $ 550.00
  • CSNpharm
  • SC-26196
  • 50mg
  • $ 656.00
Total 15 raw suppliers
Chemical Property of α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile
Chemical Property:
  • PSA：55.52000 
  • LogP:4.19898 
  • Storage Temp.:Store at -20°C 
  • Solubility.:DMSO: ≥10mg/mL 
Purity/Quality:

99%, *data from raw suppliers

SC-26196 *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:
Useful:
  • Description The enzyme Δ6 desaturase mediates the conversion of linoleic acid to γ-linolenic acid (GLA), which can then be elongated to dihomo-γ-linolenic acid (DGLA). DGLA can then be used as a substrate for Δ5 desaturase to produce arachidonic acid (AA), the fatty acid that is used to generate eicosanoids. SC 26196 is an inhibitor of Δ6 desaturase (IC50 = 0.2 μM in a rat liver microsomal assay) that completely blocks the conversion of linoleic acid to arachidonic acid (AA). It is selective for Δ6 desaturase, as IC50 values for Δ5 and Δ9 desaturases exceed 200 μM and it has no effect on the conversion of dihomo-γ-linolenic acid to AA. SC 26196 is orally active in vivo, decreasing edema in the carrageenan paw edema model in mice. It also blocks aging-related increases in AA in myocardial cardiolipin in mice, attenuating contractile dysfunction without impacting mitochondrial oxidative stress.
  • Uses SC-26196 has been used as an inhibitor of delta6 (Δ6) fatty acid desaturase: in mouse inner medullary?collecting duct?(IMCD3) and human (female) embryonic kidney (HEK) 293 cell culture as Dulbecco′s modified eagle′s medium (DMEM) componentin hepatic HepG2 cellsin glioblastoma cell lines to test its effect post-radiation treatments A selective Δ6 desaturase inhibitor (IC50 = 0.2 μM in vitro). Displays selectivity over Δ5 and Δ9 desaturases (IC50 values are >200 μM in vitro). It exhibits anti-inflammatory properties in a mouse edema model.
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