6-AcetaMido-2-aMino-4,5,6,7-tetrahydrobenzothiazole

Base Information

• Chemical Name: 6-AcetaMido-2-aMino-4,5,6,7-tetrahydrobenzothiazole
• CAS No.: 106006-80-8
• Molecular Formula: C9H13N3OS
• Molecular Weight: 211.288
• Mol file: 106006-80-8.mol

Synonyms:6-Acetamido-2-amino-4,5,6,7-tetrahydrobenzothiazole;6-Acetamido-2-amino-4,5,6,7tetrahydrobenzothiazole;.6-acetylamino-2-amino-4,5,6,7-tetrahydro-benzthiazole;

Chemical Property of 6-AcetaMido-2-aMino-4,5,6,7-tetrahydrobenzothiazole

Chemical Property:

• PSA: 96.25000
• LogP: 1.69080

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-AcetaMido-2-aMino-4,5,6,7-tetrahydrobenzothiazole

There total 5 articles about 6-AcetaMido-2-aMino-4,5,6,7-tetrahydrobenzothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.7%

thiourea (17356-08-0) + 2-bromo-4-acetamidocyclohexanone (687639-03-8) → N-(2-amino-4,5,6,7-tetrahydrobenzo[1,2-d]thiazol-6-yl)acetamide (106006-80-8,104617-51-8)

Guidance literature:

at 60 ℃; Reflux;

DOI:10.1021/acs.jmedchem.5b00489

Reference yield: 37.4%

N-(4-oxocyclohexyl)acetamide (27514-08-5) + thiourea (17356-08-0) → N-(2-amino-4,5,6,7-tetrahydrobenzo[1,2-d]thiazol-6-yl)acetamide (106006-80-8,104617-51-8)

Guidance literature:

N-(4-oxocyclohexyl)acetamide; With bromine; acetic acid; at 20 ℃; for 3h;

thiourea; at 110 - 120 ℃; for 0.5h;

Reference yield:

N-(4-oxocyclohexyl)acetamide (27514-08-5) + bis(formamidine)disulphide dihydrobromide (1071-86-9,19040-64-3,50606-57-0) → N-(2-amino-4,5,6,7-tetrahydrobenzo[1,2-d]thiazol-6-yl)acetamide (106006-80-8,104617-51-8)

Guidance literature:

In water;

upstream raw materials:

N-(4-oxocyclohexyl)acetamide

thiourea

2-bromo-4-acetamidocyclohexanone

bis(formamidine)disulphide dihydrobromide

Downstream raw materials:

{(R)-1-[(S)-2-(2-Amino-4,5,6,7-tetrahydro-benzothiazol-6-ylcarbamoyl)-pyrrolidine-1-carbonyl]-2,2-diphenyl-ethyl}-carbamic acid tert-butyl ester

tert-butyl (1R)-2-((2S)-2-{[(2-amino-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl)amino]carbonyl}pyrrolidinyl)-1-(3,4-dichlorobenzyl)-2-oxoethylcarbamate

tert-butyl 2-[[(1R)-2-((2S)-{[(2-amino-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl)amino]carbonyl}pyrrolidinyl)-1-(cyclohexylmethyl)-2-oxoethyl](tert-butyoxycarbonyl)amino]acetate

6-acetylamino-2-benzoylamino-4,5,6,7-tetrahydro-benzthiazole