3-IODO-1,4-DIHYDRO-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE

Base Information

• Chemical Name: 3-IODO-1,4-DIHYDRO-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE
• CAS No.: 142189-88-6
• Molecular Formula: C5H3IN4O
• Molecular Weight: 262.00800
• Hs Code.: 2933399990
• Mol file: 142189-88-6.mol

Synonyms:3-iodopyrazolo<4,3-d>pyrimidin-7-one;3-iodopropyltrichlorosilane;

Chemical Property of 3-IODO-1,4-DIHYDRO-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE

Chemical Property:

• PSA: 74.69000
• LogP: 0.66310

Purity/Quality:

97% ^*data from raw suppliers

1,6-Dihydro-3-iodo-7H-Pyrazolo[4,3-d]pyrimidin-7-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-IODO-1,4-DIHYDRO-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE

There total 1 articles about 3-IODO-1,4-DIHYDRO-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

pyrazolo<4,3-d>pyrimidin-7-one (13877-55-9) → 3-iodopyrazolo<4,3-d>pyrimidin-7-one (142189-88-6)

Guidance literature:

With N-iodo-succinimide; In N,N-dimethyl-formamide; at 60 ℃; for 5h;

DOI:10.1021/jo00043a029

Reference yield: 81.0%

3-iodopyrazolo<4,3-d>pyrimidin-7-one (142189-88-6) + tert-butylchlorodiphenylsilane (58479-61-1) → 3-iodo-1-<(1,1-dimethylethyl)diphenylsilyl>-7-<<(1,1-dimethylethyl)diphenylsilyl>oxy>pyrazolo<4,3-d>pyrimidine (142189-89-7)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 80 ℃; for 3h;

DOI:10.1021/jo00043a029

Reference yield:

3-iodopyrazolo<4,3-d>pyrimidin-7-one (142189-88-6) → 1-[(4-[2-[4-(difluoromethoxy)phenyl]ethyl]-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl]-6-methyl-7-oxo-1H,6H,7H-pyrazolo[4,3-d]pyrimidine-3-carbonitrile

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 12.33 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C

2.2: 3 h / 20 °C

3.1: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 1 h / 100 °C / Microwave irradiation; Inert atmosphere

4.1: trifluoroacetic acid / 18 h / 60 °C

5.1: triphenylphosphine; di-isopropyl azodicarboxylate / N,N-dimethyl-formamide / 0.5 h / 20 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 1,1'-bis-(diphenylphosphino)ferrocene; di-isopropyl azodicarboxylate; sodium hydride; triphenylphosphine; trifluoroacetic acid; In N,N-dimethyl-formamide;

upstream raw materials:

pyrazolo<4,3-d>pyrimidin-7-one

Downstream raw materials:

3-iodo-1-<(1,1-dimethylethyl)diphenylsilyl>-7-<<(1,1-dimethylethyl)diphenylsilyl>oxy>pyrazolo<4,3-d>pyrimidine

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