5-broMo-3-iodo-1-tosyl-1H-indole

Base Information

• Chemical Name: 5-broMo-3-iodo-1-tosyl-1H-indole
• CAS No.: 142688-28-6
• Molecular Formula: C15H11BrINO2S
• Molecular Weight: 476.132
• Mol file: 142688-28-6.mol

Synonyms:5-bromo-3-iodo-1-tosylindole;5-bromo-3-iodo-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridine;5-Bromo-3-iodo-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine;5-bromo-3-iodo-1-tosyl-1H-pyrrolo[2,3-6]pyridine;5-bromo-3-iodo-1-tosyl-1H-indole;5-bromo-3-iodo-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine,5-bromo-3-iodo-1-[(4-methylphenyl)sulfonyl];5-bromo-3-iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridine;

Chemical Property of 5-broMo-3-iodo-1-tosyl-1H-indole

Chemical Property:

• PSA: 47.45000
• LogP: 5.63460

Purity/Quality:

NLT 98% ^*data from raw suppliers

5-Bromo-3-iodo-1-tosyl-1H-indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-broMo-3-iodo-1-tosyl-1H-indole

There total 3 articles about 5-broMo-3-iodo-1-tosyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-bromo-3-iodo-1H-indole (868694-19-3) + p-toluenesulfonyl chloride (98-59-9) → 5-bromo-3-iodo-1-tosyl-1H-indole (142688-28-6)

Guidance literature:

5-bromo-3-iodo-1H-indole; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

p-toluenesulfonyl chloride; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1016/j.bmcl.2018.05.054

Reference yield: 74.0%

5-bromo-1H-indole (10075-50-0) + p-toluenesulfonyl chloride (98-59-9) → 5-bromo-3-iodo-1-tosyl-1H-indole (142688-28-6)

Guidance literature:

5-bromo-1H-indole; With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

With iodine; In N,N-dimethyl-formamide; for 1h; Inert atmosphere;

p-toluenesulfonyl chloride; With potassium hydroxide; In N,N-dimethyl-formamide; Inert atmosphere;

DOI:10.1021/acs.orglett.9b02687

Reference yield:

5-bromo-1H-indole (10075-50-0) → 5-bromo-3-iodo-1-tosyl-1H-indole (142688-28-6)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 0.5 h / 20 °C

2: potassium hydroxide / N,N-dimethyl-formamide / 3 h / 20 °C

With iodine; potassium hydroxide; In N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201300133

upstream raw materials:

5-bromo-3-iodo-1H-indole

p-toluenesulfonyl chloride

5-bromo-1H-indole

Downstream raw materials:

5-Bromo-3-pyridin-3-yl-1-(toluene-4-sulfonyl)-1H-indole

N-{3-[5-bromo-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-prop-2-ynyl}-4-methyl-benzenesulfonamide

5-bromo-3-(3-methoxy-phenyl)-1-(toluene-4-sulfonyl)-1H-indole

5-Phenyl-3-pyridin-3-yl-1-(toluene-4-sulfonyl)-1H-indole

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 142688-28-6 5-broMo-3-iodo-1-tosyl-1H-indole

Send

Send

Metric Ton KG G Pound L ML

Send

Send