tert-Butyl 5-(benzyloxy)-1H-indole-1-carboxylate

Base Information

• Chemical Name: tert-Butyl 5-(benzyloxy)-1H-indole-1-carboxylate
• CAS No.: 170147-29-2
• Molecular Formula: C20H21NO3
• Molecular Weight: 323.392
• Mol file: 170147-29-2.mol

Synonyms:5-Benzyloxy-indole-1-carboxylic acid tert-butyl ester;5-amino-2-Boc-1,2,3,4-tetrahydro-isoquinoline;5-Benzyloxy-1-tert-butoxycarbonyl-1H-indole;tert-butyl 5-benzyloxy-1H-indole-1-carboxylate;tert-butyl 5-amino-1,2,3,4-tetrahydroisoquinoline-2-carboxylate;5-amino-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester;

Chemical Property of tert-Butyl 5-(benzyloxy)-1H-indole-1-carboxylate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 460.878oC at 760 mmHg
• Flash Point: 232.531oC
• PSA: 40.46000
• Density: 1.104g/cm3
• LogP: 5.00350
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl5-(benzyloxy)-1H-indole-1-carboxylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl 5-(benzyloxy)-1H-indole-1-carboxylate

There total 2 articles about tert-Butyl 5-(benzyloxy)-1H-indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

5-benzyloxy-1H-indole (1215-59-4) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 5-(benzyloxy)-1H-indole-1-carboxylate (170147-29-2)

Guidance literature:

With dmap; In dichloromethane; at 20 ℃; for 15h;

Reference yield:

5-benzyloxy-1H-indole (1215-59-4) + di-tert-butyl dicarbonate (24424-99-5) + potassium tert-butylate (865-47-4) → tert-butyl 5-(benzyloxy)-1H-indole-1-carboxylate (170147-29-2)

Guidance literature:

In N,N-dimethyl-formamide;

Reference yield: 100.0%

tert-butyl 5-(benzyloxy)-1H-indole-1-carboxylate (170147-29-2) → 1-tert-butyloxycarbonyl-5-benzyloxy-indole-2-boronic acid (850568-62-6)

Guidance literature:

With Triisopropyl borate; In tetrahydrofuran; n-heptane; ethylbenzene; for 2.41667h; Cooling with ice;

upstream raw materials:

5-benzyloxy-1H-indole

di-tert-butyl dicarbonate

potassium tert-butylate

Downstream raw materials:

tert-butyl 5-hydroxy-2,3-dihydroindole-1-carboxylate

1-tert-butyloxycarbonyl-5-benzyloxy-indole-2-boronic acid

C₂₀H₁₅FN₂O

C₂₁H₁₅F₃N₂O