Methyl 2-(2,2,2-trifluoroacetamido)imidazo[1,2-A]pyridine-6-carboxylate

Base Information

Chemical Name:Methyl 2-(2,2,2-trifluoroacetamido)imidazo[1,2-A]pyridine-6-carboxylate
CAS No.:209971-50-6
Molecular Formula:C11H8F3N3O3
Molecular Weight:287.19500
Hs Code.:2933990090
DSSTox Substance ID:DTXSID00450203
Nikkaji Number:J974.983G
Mol file:209971-50-6.mol

Synonyms:209971-50-6;METHYL 2-(2,2,2-TRIFLUOROACETAMIDO)IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE;METHYL 2-(2,2,2-TRIFLUORO-ACETYLAMINO)-IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE;methyl 2-[(2,2,2-trifluoroacetyl)amino]imidazo[1,2-a]pyridine-6-carboxylate;SCHEMBL251221;DTXSID00450203;AB18827;CS-0449828;FT-0725272;2-(Trifluoroacetylamino)imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester;METHYL2-(2,2,2-TRIFLUOROACETAMIDO)IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE

Suppliers and Price of Methyl 2-(2,2,2-trifluoroacetamido)imidazo[1,2-A]pyridine-6-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
Methyl 2-(trifluoroacetamido)imidazo[1,2-a]pyridine-6-carboxylate 98%
1 g
$ 1814.00

SynQuest Laboratories
Methyl 2-(trifluoroacetamido)imidazo[1,2-a]pyridine-6-carboxylate 98%
250 mg
$ 673.00

J&W Pharmlab
Methyl2-(2,2,2-Trifluoro-acetylamino)-imidazo[1,2-a]pyridine-6-carboxylate 96%
5g
$ 6998.00

J&W Pharmlab
Methyl2-(2,2,2-Trifluoro-acetylamino)-imidazo[1,2-a]pyridine-6-carboxylate 96%
1g
$ 1880.00

Crysdot
Methyl2-(2,2,2-trifluoroacetamido)imidazo[1,2-a]pyridine-6-carboxylate 95+%
1g
$ 608.00

Chemenu
Methyl2-(2,2,2-Trifluoro-acetylamino)-imidazo[1,2-a]pyridine-6-carboxylate 95%
1g
$ 574.00

Total 7 raw suppliers

Chemical Property of Methyl 2-(2,2,2-trifluoroacetamido)imidazo[1,2-A]pyridine-6-carboxylate

Chemical Property:

PSA：72.70000
LogP:1.69470
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:287.05177561
Heavy Atom Count:20
Complexity:402

Purity/Quality:

97% ^*data from raw suppliers

Methyl 2-(trifluoroacetamido)imidazo[1,2-a]pyridine-6-carboxylate 98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1=CN2C=C(N=C2C=C1)NC(=O)C(F)(F)F

Technology Process of Methyl 2-(2,2,2-trifluoroacetamido)imidazo[1,2-A]pyridine-6-carboxylate

There total 5 articles about Methyl 2-(2,2,2-trifluoroacetamido)imidazo[1,2-A]pyridine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 407-25-0
trifluoroacetic anhydride

: 209971-47-1
1-Carbamoylmethyl-6-[(E)-toluene-4-sulfonylimino]-1,6-dihydro-pyridine-3-carboxylic acid methyl ester

: 209971-50-6
methyl 2-(2,2,2-trifluoroacetamido)imidazo[1,2-a]pyridine-6-carboxylate

Guidance literature:: In dichloromethane; for 3h; Heating;
DOI:10.1055/s-1998-2078

Reference yield:

: 1208250-24-1
methyl 1-(2-amino-2-oxoethyl)-6-(4-methylphenylsulfonamido)-1,6-dihydropyridine-3-carboxylate

: 407-25-0
trifluoroacetic anhydride

: 209971-50-6
methyl 2-(2,2,2-trifluoroacetamido)imidazo[1,2-a]pyridine-6-carboxylate

Guidance literature:: methyl 1-(2-amino-2-oxoethyl)-6-(4-methylphenylsulfonamido)-1,6-dihydropyridine-3-carboxylate; trifluoroacetic anhydride; In dichloromethane; at 20 ℃; Reflux;

With sodium hydrogencarbonate; for 0.25h;

Reference yield:

: 36052-24-1
methyl 6-aminonicotinoate

: 209971-50-6
methyl 2-(2,2,2-trifluoroacetamido)imidazo[1,2-a]pyridine-6-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / pyridine / 80 - 90 °C

2: 92 percent / i-Pr₂NEt / dimethylformamide / 24 h / 23 °C

3: 49 percent / CH₂Cl₂ / 3 h / Heating

With pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-1998-2078