N-(3-AMino[1,1'-biphenyl]-4-yl)-carbaMic Acid tert-Butyl Ester

Base Information Edit

Chemical Name:N-(3-AMino[1,1'-biphenyl]-4-yl)-carbaMic Acid tert-Butyl Ester
CAS No.:335255-33-9
Molecular Formula:C17H20N2O2
Molecular Weight:284.358
Hs Code.:
Mol file:335255-33-9.mol

Synonyms:N-(3-Amino[1,1'-biphenyl]-4-yl)-carbamic Acid tert-Butyl Ester;

Suppliers and Price of N-(3-AMino[1,1'-biphenyl]-4-yl)-carbaMic Acid tert-Butyl Ester

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-(3-Amino[1,1''-biphenyl]-4-yl)-carbamicAcidtert-ButylEster
500mg
$ 1230.00

Medical Isotopes, Inc.
N-(3-Amino[1,1??-biphenyl]-4-yl)-carbamicAcidtert-ButylEster
50 mg
$ 640.00

Matrix Scientific
tert-Butyl (3-amino-[1,1'-biphenyl]-4-yl)carbamate 95%
10g
$ 4810.00

Matrix Scientific
tert-Butyl (3-amino-[1,1'-biphenyl]-4-yl)carbamate 95%
5g
$ 3146.00

Total 2 raw suppliers

Chemical Property of N-(3-AMino[1,1'-biphenyl]-4-yl)-carbaMic Acid tert-Butyl Ester Edit

Chemical Property:

Boiling Point:400.6±45.0 °C(Predicted)
PKA:13.24±0.70(Predicted)
PSA：64.35000
Density:1.155±0.06 g/cm3(Predicted)
LogP:4.93700
Storage Temp.:Refrigerator
Solubility.:Chloroform, Dichloromethane, Methanol

Purity/Quality:

98% ^*data from raw suppliers

N-(3-Amino[1,1''-biphenyl]-4-yl)-carbamicAcidtert-ButylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses N-(3-Amino[1,1'-biphenyl]-4-yl)-carbamic Acid tert-Butyl Ester is a reactant used in the optimization of selective HDAC1/HDAC2 inhibitor, preparation of non-competitive metabotropic glutamate receptor 2/3 antagonists

Technology Process of N-(3-AMino[1,1'-biphenyl]-4-yl)-carbaMic Acid tert-Butyl Ester

There total 6 articles about N-(3-AMino[1,1'-biphenyl]-4-yl)-carbaMic Acid tert-Butyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 335254-77-8
tert-butyl (3-nitro-[1, 1'-biphenyl]-4-yl)carbamate

: 335255-33-9
tert-butyl (3-amino-4-biphenylyl)carbamate

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In methanol; dichloromethane; at 20 ℃;
DOI:10.1002/cmdc.202100755

Reference yield:

: 327046-79-7
tert-butyl (4-bromo-2-nitrophenyl)carbamate

: 335255-33-9
tert-butyl (3-amino-4-biphenylyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / 1,4-dioxane; water monomer / 0.5 h / Inert atmosphere

1.2: 20 h / 90 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In 1,4-dioxane; water monomer; ethyl acetate;
DOI:10.1021/ml4004233

Reference yield:

: 875-51-4
4-Bromo-2-nitroaniline

: 335255-33-9
tert-butyl (3-amino-4-biphenylyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; dmap / dichloromethane

2.1: potassium carbonate / 1,4-dioxane; water / 0.5 h / Inert atmosphere

2.2: 20 h / 90 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / Inert atmosphere

With dmap; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; water; ethyl acetate;
DOI:10.1021/ml4004233