tert-Butyl (3-amino-4-fluorophenyl)carbamate

Base Information

Chemical Name:tert-Butyl (3-amino-4-fluorophenyl)carbamate
CAS No.:361548-95-0
Molecular Formula:C11H15FN2O2
Molecular Weight:226.251
Hs Code.:2924299090
European Community (EC) Number:808-728-8
DSSTox Substance ID:DTXSID80472882
Wikidata:Q82302070
Mol file:361548-95-0.mol

Synonyms:361548-95-0;tert-Butyl (3-amino-4-fluorophenyl)carbamate;(3-AMINO-4-FLUORO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER;tert-butyl 3-amino-4-fluorophenylcarbamate;TERT-BUTYL N-(3-AMINO-4-FLUOROPHENYL)CARBAMATE;MFCD04114550;2-Methyl-2-Propanyl (3-Amino-4-Fluorophenyl)Carbamate;Tert-butyl N-(3-amino-4-fluoro-phenyl)carbamate;SCHEMBL1094945;DTXSID80472882;VWFNJRUKTFGZJN-UHFFFAOYSA-N;AMY28001;N1-Boc-4-fluoro-1,3-benzenediamine;AKOS000169343;CARBAMIC ACID, (3-AMINO-4-FLUOROPHENYL)-, 1,1-DIMETHYLETHYL ESTER;AB18553;CS-13018;SY170126;CS-0040890;FT-0708705;tert-Butyl(3-amino-4-fluorophenyl)carbamate;EN300-36325;W17031;A823146;(3-Amino-4-fluorophenyl)carbamicacidtert-butylester;(3-amino-4-fluorophenyl)carbamic acid tert-butyl ester;Z285919696;(3-Amino-4-fluoro-phenyl)-carbamic acid tert-butyl ester, AldrichCPR

Suppliers and Price of tert-Butyl (3-amino-4-fluorophenyl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(3-Amino-4-fluoro-phenyl)-carbamicAcidtert-ButylEster
100mg
$ 65.00

TRC
(3-Amino-4-fluoro-phenyl)-carbamicAcidtert-ButylEster
500mg
$ 240.00

SynQuest Laboratories
tert-Butyl N-(3-amino-4-fluorophenyl)carbamate 97%
1 g
$ 332.00

SynQuest Laboratories
tert-Butyl N-(3-amino-4-fluorophenyl)carbamate 97%
250 mg
$ 161.00

J&W Pharmlab
(3-Amino-4-fluoro-phenyl)-carbamicacidtert-butylester 97%
250mg
$ 95.00

J&W Pharmlab
(3-Amino-4-fluoro-phenyl)-carbamicacidtert-butylester 97%
100mg
$ 85.00

J&W Pharmlab
(3-Amino-4-fluoro-phenyl)-carbamicacidtert-butylester 97%
500mg
$ 115.00

J&W Pharmlab
(3-Amino-4-fluoro-phenyl)-carbamicacidtert-butylester 97%
1g
$ 185.00

J&W Pharmlab
(3-Amino-4-fluoro-phenyl)-carbamicacidtert-butylester 97%
5g
$ 740.00

Crysdot
tert-Butyl(3-amino-4-fluorophenyl)carbamate 95+%
5g
$ 752.00

Total 19 raw suppliers

Chemical Property of tert-Butyl (3-amino-4-fluorophenyl)carbamate

Chemical Property:

PSA：64.35000
LogP:3.40910
XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:226.11175589
Heavy Atom Count:16
Complexity:253

Purity/Quality:

97% ^*data from raw suppliers

(3-Amino-4-fluoro-phenyl)-carbamicAcidtert-ButylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC1=CC(=C(C=C1)F)N

Technology Process of tert-Butyl (3-amino-4-fluorophenyl)carbamate

There total 7 articles about tert-Butyl (3-amino-4-fluorophenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 332370-72-6
N-(tert-butoxycarbonyl)-4-fluoro-3-nitroaniline

: 361548-95-0
(3-amino-4-fluorophenyl)carbamic acid t-butyl ester

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 27 ℃; for 16h; Inert atmosphere;

Reference yield:

: 456-22-4
4-Fluorobenzoic acid

: 361548-95-0
(3-amino-4-fluorophenyl)carbamic acid t-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / KNO₃; conc. H₂SO₄ / 20 °C

2: oxalyl chloride; DMF / CH₂Cl₂ / 20 °C

3: sodium azide / CH₂Cl₂; dimethylformamide / 20 °C

4: CH₂Cl₂; dimethylformamide / Heating

5: 47 percent / H₂ / palladium black / methanol / 20 °C

With sodium azide; oxalyl dichloride; sulfuric acid; hydrogen; potassium nitrate; N,N-dimethyl-formamide; palladium; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0205090

Reference yield:

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 361548-95-0
(3-amino-4-fluorophenyl)carbamic acid t-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 20 °C

2: sodium azide / CH₂Cl₂; dimethylformamide / 20 °C

3: CH₂Cl₂; dimethylformamide / Heating

4: 47 percent / H₂ / palladium black / methanol / 20 °C

With sodium azide; oxalyl dichloride; hydrogen; N,N-dimethyl-formamide; palladium; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0205090