Technology Process of 5-AMINOMETHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER
There total 7 articles about 5-AMINOMETHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethanol;
for 2h;
under 1551.44 Torr;
DOI:10.1021/jm020230j
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: NaBH4 / tetrahydrofuran / 0.5 h
2.1: 10.6 g / imidazole / CH2Cl2 / 0.5 h / 20 °C
3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C
3.2: 97 percent / tetrahydrofuran; hexane / 1 h / -78 °C
4.1: acetic acid; tetrabutylammonium fluoride / tetrahydrofuran / 12 h
5.1: 4 percent / CBr4; triphenylphosphine / tetrahydrofuran / 1 h
6.1: sodium azide / dimethylformamide / 0.5 h / 50 °C
7.1: H2 / 10 percent Pd/C / ethanol / 2 h / 1551.44 Torr
With
1H-imidazole; sodium tetrahydroborate; n-butyllithium; sodium azide; carbon tetrabromide; tetrabutyl ammonium fluoride; hydrogen; acetic acid; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm020230j
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 10.6 g / imidazole / CH2Cl2 / 0.5 h / 20 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C
2.2: 97 percent / tetrahydrofuran; hexane / 1 h / -78 °C
3.1: acetic acid; tetrabutylammonium fluoride / tetrahydrofuran / 12 h
4.1: 4 percent / CBr4; triphenylphosphine / tetrahydrofuran / 1 h
5.1: sodium azide / dimethylformamide / 0.5 h / 50 °C
6.1: H2 / 10 percent Pd/C / ethanol / 2 h / 1551.44 Torr
With
1H-imidazole; n-butyllithium; sodium azide; carbon tetrabromide; tetrabutyl ammonium fluoride; hydrogen; acetic acid; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm020230j
