7-Methyl-2-phenyl-1H-indole

Base Information

• Chemical Name: 7-Methyl-2-phenyl-1H-indole
• CAS No.: 59541-82-1
• Molecular Formula: C15H13N
• Molecular Weight: 207.275
• Mol file: 59541-82-1.mol

Synonyms:1H-INDOLE,7-METHYL-2-PHENYL-;

Chemical Property of 7-Methyl-2-phenyl-1H-indole

Chemical Property:

• PSA: 15.79000
• LogP: 4.14330

Purity/Quality:

97% ^*data from raw suppliers

1H-Indole,7-methyl-2-phenyl- 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Methyl-2-phenyl-1H-indole

There total 56 articles about 7-Methyl-2-phenyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-methyl-6-phenacyl-cyclohexanone (144536-59-4) → 7-methyl-2-phenyl-1H-indole (59541-82-1)

Guidance literature:

With ethene; 5%-palladium/activated carbon; ammonium acetate; In 1,4-dioxane; at 110 ℃; under 760.051 Torr; Schlenk technique;

DOI:10.1021/acs.orglett.0c04056

Reference yield: 89.0%

2-(2,2-dibromovinyl)-6-methyl-phenylamine + phenylboronic acid (98-80-6) → 7-methyl-2-phenyl-1H-indole (59541-82-1)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; In toluene; at 100 ℃; for 2h;

DOI:10.1021/jo701987r

Reference yield: 86.0%

1-phenyl-2-(2-methylphenylamino)ethanone (77919-44-9) + o-toluidine (95-53-4) → 7-methyl-2-phenyl-1H-indole (59541-82-1)

Guidance literature:

1-phenyl-2-(2-methylphenylamino)ethanone; o-toluidine; With triphenylphosphine; palladium(II) bromide; In 2,2,2-trifluoroethanol; toluene; for 0.25h; Schlenk technique; Inert atmosphere;

With hydrogen; sodium sulfate; In 2,2,2-trifluoroethanol; toluene; at 150 ℃; for 24h; under 41372.9 Torr; regioselective reaction; Autoclave; Schlenk technique;

DOI:10.1002/ejoc.201900394

upstream raw materials:

2-anilinoacetophenone

o-toluidine hydrochloride

1-phenyl-2-(2-methylphenylamino)ethanone

aniline hydrobromide

Downstream raw materials:

7-methyl-2-phenyl-indole-3-carbaldehyde

(7-methyl-2-phenylindol-3-yl)glyoxylyl chloride

7-methyl-2-phenyl-1H-indole-3-carbonitrile

1,7-dimethyl-2-phenyl-1H-indole