2-Acetylamino-5-iodopyridine

Base Information

• Chemical Name: 2-Acetylamino-5-iodopyridine
• CAS No.: 66131-78-0
• Molecular Formula: C7H7IN2O
• Molecular Weight: 262.05
• Hs Code.: 2933399990
• DSSTox Substance ID: DTXSID30363392
• Wikidata: Q72484537
• Mol file: 66131-78-0.mol

Synonyms:2-ACETYLAMINO-5-IODOPYRIDINE;66131-78-0;N-(5-iodopyridin-2-yl)acetamide;N-(5-Iodo-2-pyridinyl)acetamide;2-Acetamido-5-iodopyridine;N-(5-Iodo-pyridin-2-yl)-acetamide;Bionet2_000792;Oprea1_485768;SCHEMBL761089;DTXSID30363392;HMS1366D22;MFCD01315262;AKOS004010618;AB08522;CS-0141661;FT-0680724;9L-901;T71190;J-523119

Chemical Property of 2-Acetylamino-5-iodopyridine

Chemical Property:

• Vapor Pressure: 8.96E-07mmHg at 25°C
• Melting Point: 156-158oC
• Boiling Point: 405.2oC at 760 mmHg
• PKA: 13.08±0.70(Predicted)
• Flash Point: 198.8oC
• PSA: 41.99000
• Density: 1.901g/cm3
• LogP: 1.71760
• Storage Temp.: 2-8°C
• Solubility.: soluble in Methanol
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 261.96031
• Heavy Atom Count: 11
• Complexity: 151

Purity/Quality:

98%min ^*data from raw suppliers

2-Acetamido-5-iodopyridine >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=NC=C(C=C1)I

Technology Process of 2-Acetylamino-5-iodopyridine

There total 3 articles about 2-Acetylamino-5-iodopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.6%

2-amino-5-iodopyridine (20511-12-0) + acetic anhydride (108-24-7) → N-(5-iodo-pyridin-2-yl)acetamide (66131-78-0)

Guidance literature:

With dmap; In 1,2-dichloro-ethane; at 60 ℃; for 6h;

Reference yield: 63.0%

→ N-(5-iodo-pyridin-2-yl)acetamide (66131-78-0)

Guidance literature:

With pyridine; at 20 - 35 ℃; for 16h;

Reference yield:

2-aminopyridine (504-29-0) → N-(5-iodo-pyridin-2-yl)acetamide (66131-78-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / I₂, KI / H₂O

2: 82 percent / acetic acid

With iodine; potassium iodide; In water; acetic acid;

DOI:10.1016/0960-894X(96)00129-1

upstream raw materials:

2-amino-5-iodopyridine

acetic anhydride

2-aminopyridine

Refernces

• 1、 Konno, Hiroyuki,Sato, Taki,Saito, Yugo,Sakamoto, Iori,Akaji, Kenichi. "Synthesis and evaluation of aminopyridine derivatives as potential BACE1 inhibitors". supporting information. p. 5127 - 5132. Retrieved 2015/11/09.
• 2、 Varvaresou,Tsotinis,Papadaki-Valiraki,Siatra-Papastaikoudi. "Synthesis and structure elucidation of new cytotoxic azathioxanthones". . p. 917 - 921. Retrieved 2007/10/03.