(2R)-3-(O-ALLYLOXYPHENOXY)-1,2-EPOXYPROPANE

Base Information

• Chemical Name: (2R)-3-(O-ALLYLOXYPHENOXY)-1,2-EPOXYPROPANE
• CAS No.: 66966-19-6
• Molecular Formula: C12H14O3
• Molecular Weight: 206.23800
• Mol file: 66966-19-6.mol

Synonyms:

Chemical Property of (2R)-3-(O-ALLYLOXYPHENOXY)-1,2-EPOXYPROPANE

Chemical Property:

• Boiling Point: 305.1±17.0 °C(Predicted)
• PSA: 30.99000
• Density: 1.109±0.06 g/cm3(Predicted)
• LogP: 2.02900

Purity/Quality:

97% ^*data from raw suppliers

(2R)-3-(O-ALLYLOXYPHENOXY)-1,2-EPOXYPROPANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R)-3-(O-ALLYLOXYPHENOXY)-1,2-EPOXYPROPANE

There total 25 articles about (2R)-3-(O-ALLYLOXYPHENOXY)-1,2-EPOXYPROPANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

S-oxiran-2-ylmethyl 4-nitrobenzenesulfonate (118712-60-0,118629-64-4) + 2-allyloxyphenol (1126-20-1) → (S)-3-(2-allyloxyphenoxy)-1,2-epoxypropane (66966-20-9,66966-19-6)

Guidance literature:

With potassium carbonate; cesium fluoride; In N,N-dimethyl-formamide; for 24h; Ambient temperature;

DOI:10.1016/S0040-4039(98)00452-3

Reference yield: 95.0%

(2s)-(+)-glycidyl 3-nitrobenzenesulfonate (115314-14-2) + 2-allyloxyphenol (1126-20-1) → (S)-3-(2-allyloxyphenoxy)-1,2-epoxypropane (66966-20-9,66966-19-6)

Guidance literature:

With cesium fluoride; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Further Variations:; Reaction partners; Reagents; Product distribution;

DOI:10.1016/S0040-4020(99)00896-0

Reference yield: 86.0%

(R)-(-)-epichlorohydrin (51594-55-9,24969-06-0,13403-37-7) + 2-allyloxyphenol (1126-20-1) → (S)-3-(2-allyloxyphenoxy)-1,2-epoxypropane (66966-20-9,66966-19-6)

Guidance literature:

With sodium hydroxide; benzyltrimethylammonium chloride; In water; toluene; at 0 - 20 ℃; for 48.75h;

upstream raw materials:

(R)-3-(2-allyloxy phenoxy)-1-chloro-2-propanol

epichlorohydrin

2-allyloxyphenol

(S)-Glycidyl tosylate

Downstream raw materials:

(R)-2-allyloxy-1-(2,3-dihydroxypropoxy)benzene

N-({2-[3-(2-Allyloxy-phenoxy)-2-hydroxy-propylamino]-ethylcarbamoyl}-methyl)-4-chloro-benzamide

1-(2-Allyloxy-phenoxy)-3-{6-[3-(2-allyloxy-phenoxy)-2-hydroxy-propylamino]-hexylamino}-propan-2-ol

N-{2-[3-(2-Allyloxy-phenoxy)-2-hydroxy-propylamino]-ethyl}-isobutyramide

Refernces

• 1、 -. "PROCESS FOR PRODUCING GLYCIDYL ETHER". Page 5 - 6. . Retrieved 2008/06/13.
• 2、 Apparu, Marcel,Ben Tiba, Younes,Leo, Pierre-Marc,Hamman, Sylvain,Coulombeau, Christian. "Determination of the enantiomeric purity and the configuration of β- aminoalcohols using (R)-2-fluorophenylacetic acid (AFPA) and fluorine-19 NMR: Application to β-blockers". . p. 2885 - 2898. Retrieved 2007/10/03.