3-FLUORO-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 3-FLUORO-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
• CAS No.: 695212-12-5
• Molecular Formula: C9H7FN2O2
• Molecular Weight: 194.16200
• Mol file: 695212-12-5.mol

Synonyms:

Chemical Property of 3-FLUORO-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

Chemical Property:

• PKA: 0.63±0.50(Predicted)
• PSA: 43.60000
• Density: 1.36±0.1 g/cm3(Predicted)
• LogP: 1.26000

Purity/Quality:

99% ^*data from raw suppliers

methyl3-fluoroimidazo[1,2-a]pyridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-FLUORO-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

There total 3 articles about 3-FLUORO-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

methyl 3,3,3-trifluoro-2-(pyridine-2-imino)propionate → methyl 3-fluoroimidazo[1,2-a]pyridine-2-carboxylate (695212-12-5)

Guidance literature:

With phosphorous acid trimethyl ester; In N,N-dimethyl-formamide; for 1h;

DOI:10.1007/s11172-005-0280-x

Reference yield:

2-aminopyridine (504-29-0) → methyl 3-fluoroimidazo[1,2-a]pyridine-2-carboxylate (695212-12-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / SOCl₂; pyridine / benzene / 1 h

2: 77 percent / trimethyl phosphite / dimethylformamide / 1 h

With pyridine; thionyl chloride; phosphorous acid trimethyl ester; In N,N-dimethyl-formamide; benzene;

DOI:10.1007/s11172-005-0280-x

Reference yield:

2-aminopyridine (504-29-0) → methyl 3-fluoroimidazo[1,2-a]pyridine-2-carboxylate (695212-12-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; thionyl chloride

2: phosphorous acid trimethyl ester

With pyridine; thionyl chloride; phosphorous acid trimethyl ester;

DOI:10.1134/S1070363211060223

upstream raw materials:

2-aminopyridine

Refernces

• 1、 Levov,Sokolov,Aksinenko, A.Yu.,Il'ina,Varlamov. "Modification of chitosan with ethoxycarbonyl and 3-fluoroimidazo[1,2-a] pyridine-2-carbonyl fragments". scheme or table. p. 1198 - 1202. Retrieved 2011/10/18.