Tert-Butyl 4-(3-iodo-1H-indazol-6-yl)piperazine-1-carboxylate

Base Information

• Chemical Name: Tert-Butyl 4-(3-iodo-1H-indazol-6-yl)piperazine-1-carboxylate
• CAS No.: 744219-44-1
• Molecular Formula: C16H21IN4O2
• Molecular Weight: 428.26800
• Hs Code.: 2933990090
• Mol file: 744219-44-1.mol

Synonyms:tert-butyl 4-(3-iodo-2H-indazol-6-yl)piperazine-1-carboxylate;

Chemical Property of Tert-Butyl 4-(3-iodo-1H-indazol-6-yl)piperazine-1-carboxylate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 541.709oC at 760 mmHg
• Flash Point: 281.416oC
• PSA: 61.46000
• Density: 1.6g/cm3
• LogP: 3.22750
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(3-iodo-1H-indazol-6-yl)piperazine-1-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Tert-Butyl 4-(3-iodo-1H-indazol-6-yl)piperazine-1-carboxylate

There total 1 articles about Tert-Butyl 4-(3-iodo-1H-indazol-6-yl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

tert-butyl 4-( 1H-indazol-6-yl)piperazine-1-carboxylate (744219-43-0) → 6-[4-(t-Butoxycarbonyl)piperazin-1-yl]-3-iodo-1H-indazole (744219-44-1)

Guidance literature:

With potassium hydroxide; iodine; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃;

Reference yield: 80.0%

6-[4-(t-Butoxycarbonyl)piperazin-1-yl]-3-iodo-1H-indazole (744219-44-1) + sodium benzenesulfonate (873-55-2) → 6-[4-(t-butoxycarbonyl)piperazin-1-yl]-3-iodo-1H-indazole (744219-45-2)

Guidance literature:

copper(l) iodide;

Reference yield:

6-[4-(t-Butoxycarbonyl)piperazin-1-yl]-3-iodo-1H-indazole (744219-44-1) + sodium 4-methoxybenzenesulfinate (6462-50-6) → C23H28N4O5S (1253422-89-7)

Guidance literature:

With copper(l) iodide; In N,N-dimethyl-formamide;

DOI:10.1021/jm1007825

upstream raw materials:

tert-butyl 4-( 1H-indazol-6-yl)piperazine-1-carboxylate

Downstream raw materials:

6-[4-(t-butoxycarbonyl)piperazin-1-yl]-3-iodo-1H-indazole

C₂₂H₂₅FN₄O₄S

C₂₂H₂₅ClN₄O₄S

C₂₃H₂₈N₄O₅S