5-(Benzyloxy)indoline

Base Information

• Chemical Name: 5-(Benzyloxy)indoline
• CAS No.: 92818-36-5
• Molecular Formula: C15H15NO
• Molecular Weight: 225.29
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID30588624
• Wikidata: Q82481410
• Mol file: 92818-36-5.mol

Synonyms:5-(Benzyloxy)indoline;92818-36-5;5-Benzyloxy-2,3-dihydro-1H-indole;5-Benzyloxyindoline;5-phenylmethoxy-2,3-dihydro-1H-indole;5-(benzyloxy)-2,3-dihydro-1H-indole;5-benzyloxy-indoline;SCHEMBL3875255;DTXSID30588624;NHULNFPNWXCXDI-UHFFFAOYSA-N;MFCD07371627;AKOS022175913;SB39992;AS-36259;DB-079421;CS-0094467;EN300-3097018;A844357;Z259726310

Chemical Property of 5-(Benzyloxy)indoline

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 399.959oC at 760 mmHg
• Flash Point: 159.771oC
• PSA: 21.26000
• Density: 1.131g/cm3
• LogP: 3.37160
• Storage Temp.: 2-8°C
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 225.115364102
• Heavy Atom Count: 17
• Complexity: 237

Purity/Quality:

98%Min ^*data from raw suppliers

5-Benzyloxy-2,3-dihydro-1H-indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNC2=C1C=C(C=C2)OCC3=CC=CC=C3

Technology Process of 5-(Benzyloxy)indoline

There total 4 articles about 5-(Benzyloxy)indoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

→ 5-Benzyloxy-2,3-dihydro-1H-indole (92818-36-5)

Guidance literature:

With sodium cyanoborohydride; acetic acid; at 10 ℃; for 4h;

Reference yield: 88.0%

5-benzyloxy-1H-indole (1215-59-4) → 5-Benzyloxy-2,3-dihydro-1H-indole (92818-36-5)

Guidance literature:

With sodium cyanoborohydride; acetic acid; at 20 ℃; for 1h;

Reference yield:

indol-5-ol (1953-54-4) → 5-Benzyloxy-2,3-dihydro-1H-indole (92818-36-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 24 h / Reflux

2: sodium cyanoborohydride; acetic acid / 0.17 h / 20 °C

With sodium cyanoborohydride; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;

DOI:10.1055/s-0036-1588438

upstream raw materials:

5-benzyloxy-1H-indole

indol-5-ol

benzyl bromide

Refernces

• 1、 -. "Indoline-1-formamide compound as well as preparation method and medical application thereof". Paragraph 0084-0093. . Retrieved 2019/12/02.
• 2、 -. "mTORC1 MODULATORS". Paragraph 0602; 0610-0612; 0614. . Retrieved 2019/04/30.