1H-Isoindol-1-one, 7-fluoro-2,3-dihydro-6-methoxy-

Base Information

• Chemical Name: 1H-Isoindol-1-one, 7-fluoro-2,3-dihydro-6-methoxy-
• CAS No.: 1007455-31-3
• Molecular Formula: C9H8FNO2
• Molecular Weight: 181.16400
• Mol file: 1007455-31-3.mol

Synonyms:7-fluoro-6-methoxy-2,3-dihydro-isoindol-1-one;7-FLUORO-6-METHOXYISOINDOLIN-1-ONE;7-fluoro-6-methoxylisoindolin-1-one;

Chemical Property of 1H-Isoindol-1-one, 7-fluoro-2,3-dihydro-6-methoxy-

Chemical Property:

• Boiling Point: 441.6±45.0 °C(Predicted)
• PKA: 13.21±0.20(Predicted)
• PSA: 41.82000
• Density: 1.300±0.06 g/cm3(Predicted)
• LogP: 1.08810

Purity/Quality:

99%, ^*data from raw suppliers

7-Fluoro-6-methoxyisoindolin-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Isoindol-1-one, 7-fluoro-2,3-dihydro-6-methoxy-

There total 4 articles about 1H-Isoindol-1-one, 7-fluoro-2,3-dihydro-6-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl 6-(2-aminomethyl)-2-fluoro-3-methoxybenzoate hydrochloride (1007455-30-2) → 7-fluoro-6-methoxylisoindolin-1-one (1007455-31-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In toluene; Reflux;

DOI:10.1016/j.tetlet.2008.12.099

Reference yield:

C18H14FNO5 (1219843-29-4) → 7-fluoro-6-methoxylisoindolin-1-one (1007455-31-3)

Guidance literature:

With hydrazine hydrate; In methanol; for 3h; Reflux;

Reference yield:

C17H12FNO5 (1219843-28-3) → 7-fluoro-6-methoxylisoindolin-1-one (1007455-31-3)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

2: methanol; hydrazine hydrate / 3 h / Reflux

With methanol; hydrazine hydrate; caesium carbonate; In N,N-dimethyl-formamide;

upstream raw materials:

methyl 6-(2-aminomethyl)-2-fluoro-3-methoxybenzoate hydrochloride

C₁₈H₁₄FNO₅

C₁₇H₁₂FNO₅

2-fluoro-3-methoxybenzoic acid

Downstream raw materials:

7-fluoro-6-hydroxyisoindolin-1-one

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