Technology Process of Pyrazolo[3,4-d]pyrrolo[2,3-b]pyridine, 1,6-dihydro-1-methyl-
There total 1 articles about Pyrazolo[3,4-d]pyrrolo[2,3-b]pyridine, 1,6-dihydro-1-methyl- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C
1.2: 20 °C
2.1: sec.-butyllithium / cyclohexane; tetrahydrofuran / 1.25 h / -78 °C
2.2: 1 h / -78 °C
3.1: butan-1-ol / 0.25 h / 95 °C
3.2: 4 h / 95 - 120 °C
3.3: pH 8
With
sec.-butyllithium; sodium hydride;
In
tetrahydrofuran; cyclohexane; mineral oil; butan-1-ol;
- Guidance literature:
-
1-methyl-1,6-dihydropyrazolo[3,4-d]pyrrolo[2,3-b]pyridine;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 0 ℃;
for 0.333333h;
p-toluenesulfonyl chloride;
In
N,N-dimethyl-formamide; mineral oil;
for 2h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C
1.2: 2 h
2.1: diisopropylamine; n-butyllithium / cyclohexane; tetrahydrofuran / 1.17 h / -74 °C
2.2: -74 - 20 °C
3.1: caesium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; water / 2 h / 85 °C
4.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C
With
n-butyllithium; sodium hydride; caesium carbonate; diisopropylamine; trifluoroacetic acid;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; cyclohexane; water; N,N-dimethyl-formamide; mineral oil;
