Diethyl imidazo[1,2-a]pyridine-2,8-dicarboxylate

Base Information

• Chemical Name: Diethyl imidazo[1,2-a]pyridine-2,8-dicarboxylate
• CAS No.: 133426-99-0
• Molecular Weight: 262.26
• DSSTox Substance ID: DTXSID901219736
• Mol file: 133426-99-0.mol

Synonyms:133426-99-0;diethyl imidazo[1,2-a]pyridine-2,8-dicarboxylate;IMidazo[1,2-a]pyridine-2,8-dicarboxylic acid, 2,8-diethyl ester;2,8-DIETHYL IMIDAZO[1,2-A]PYRIDINE-2,8-DICARBOXYLATE;imidazo[1,2-a]pyridine-2,8-dicarboxylic acid,2,8-diethyl ester;SCHEMBL9090050;UILHKIXKQILPDY-UHFFFAOYSA-N;DTXSID901219736;AKOS027256013;AS-71580;CS-0037889;W12260;diethylimidazo[1,2-a]pyridine-2,8-dicarboxylate;Ethyl 2-ethoxycarbonylimidazo[1,2-a]pyridine-8-carboxylate;ethyl 2-ethoxycarbonyl-imidazo[1,2-a]pyridine-8-carboxylate

Chemical Property of Diethyl imidazo[1,2-a]pyridine-2,8-dicarboxylate

Chemical Property:

• PKA: 0.48±0.50(Predicted)
• Density: 1.27±0.1 g/cm3(Predicted)
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 262.09535693
• Heavy Atom Count: 19
• Complexity: 348

Purity/Quality:

99% ^*data from raw suppliers

DiethylImidazo[1,2-A]pyridine-2,8-dicarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC(=O)C1=CC=CN2C1=NC(=C2)C(=O)OCC

Technology Process of Diethyl imidazo[1,2-a]pyridine-2,8-dicarboxylate

There total 1 articles about Diethyl imidazo[1,2-a]pyridine-2,8-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.7%

2-aminopyridine-3-carboxylic acid ethyl ester (13362-26-0) + ethyl Bromopyruvate (70-23-5) → Ethyl 2-ethoxycarbonylimidazo[1,2-a]pyridine-8-carboxylate (133426-99-0)

Guidance literature:

In butanone;

upstream raw materials:

2-aminopyridine-3-carboxylic acid ethyl ester

ethyl Bromopyruvate