2H-Pyrazolo[3,4-c]pyridin-7-amine

Base Information

• Chemical Name: 2H-Pyrazolo[3,4-c]pyridin-7-amine
• CAS No.: 948029-46-7
• Molecular Formula: C6H6N4
• Molecular Weight: 134.13900
• Mol file: 948029-46-7.mol

Synonyms:

Chemical Property of 2H-Pyrazolo[3,4-c]pyridin-7-amine

Chemical Property:

• PSA: 67.59000
• LogP: 1.12130

Purity/Quality:

99% ^*data from raw suppliers

2H-Pyrazolo[3,4-c]pyridin-7-ylamine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2H-Pyrazolo[3,4-c]pyridin-7-amine

There total 8 articles about 2H-Pyrazolo[3,4-c]pyridin-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N-(4-methyl-2-phthalimidopyridin-3-yl)-acetamide (518038-77-2) → 7-aminopyrazolo[3,4-c]pyridine (518038-78-3,948029-46-7)

Guidance literature:

N-(4-methyl-2-phthalimidopyridin-3-yl)-acetamide; With potassium acetate; acetic anhydride; isopentyl nitrite; In benzene; for 8h; Heating;

With ammonia; In methanol;

DOI:10.3987/com-02-9621

Reference yield:

2-amino-4-methyl-3-nitropyridine (6635-86-5,67476-70-4) → 7-aminopyrazolo[3,4-c]pyridine (518038-78-3,948029-46-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 78 percent / acetic acid / 24 h / Heating

2.1: 78 percent / Fe; AcOH / acetone / 1.5 h / Heating

3.1: toluene / 20 °C

4.1: AcOK; Ac₂O; isoamyl nitrite / benzene / 8 h / Heating

4.2: 82 percent / NH₃ / methanol

With potassium acetate; acetic anhydride; iron; acetic acid; isopentyl nitrite; In acetic acid; acetone; toluene; benzene;

DOI:10.3987/com-02-9621

Reference yield:

tert-butyl-N-(4-methyl-3-nitropyridin-2-yl)-carbamate (518038-71-6) → 7-aminopyrazolo[3,4-c]pyridine (518038-78-3,948029-46-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 99 percent / H₂ / 10 percent Pd/C / ethanol / 3 h / 20 °C / 2327.17 Torr

2.1: 98 percent / toluene / 1 h / 20 °C

3.1: 97 percent / CF₃CO₂H / CH₂Cl₂ / 12 h / 20 °C

4.1: 89 percent / toluene / 12 h / 50 °C

5.1: AcOK; Ac₂O; isoamyl nitrite / benzene / 8 h / Heating

5.2: 82 percent / NH₃ / methanol

With hydrogen; potassium acetate; acetic anhydride; trifluoroacetic acid; isopentyl nitrite; palladium on activated charcoal; In ethanol; dichloromethane; toluene; benzene;

DOI:10.3987/com-02-9621

upstream raw materials:

N-(4-methyl-2-phthalimidopyridin-3-yl)-acetamide

2-amino-4-methyl-3-nitropyridine

N-(2-amino-4-methylpyridin-3-yl)-acetamide

tert-butyl-N-(3-amino-4-methylpyridin-2-yl) carbamate

Downstream raw materials:

7-acetamido-1H-pyrazolo[3,4-c]pyridine

Refernces