1H-Indazole, 6-bromo-1-[[2-(trimethylsilyl)ethoxy]methyl]-

Base Information

Chemical Name:1H-Indazole, 6-bromo-1-[[2-(trimethylsilyl)ethoxy]methyl]-
CAS No.:894808-02-7
Molecular Formula:C13H19BrN2OSi
Molecular Weight:327.296
Hs Code.:

Synonyms:6-bromo-1-(-2-[trimethylsilyl]ethoxymethyl)indazole;6-bromo-1-(2-trimethylsilanyl-ethoxymethyl)-1H-indazole;

Suppliers and Price of 1H-Indazole, 6-bromo-1-[[2-(trimethylsilyl)ethoxy]methyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 1H-Indazole, 6-bromo-1-[[2-(trimethylsilyl)ethoxy]methyl]-

Chemical Property:

PSA：27.05000
LogP:4.11110

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Indazole, 6-bromo-1-[[2-(trimethylsilyl)ethoxy]methyl]-

There total 2 articles about 1H-Indazole, 6-bromo-1-[[2-(trimethylsilyl)ethoxy]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 79762-54-2
6-bromo-1H-indazole

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 894808-02-7
6-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole

Guidance literature:: With tetrabutylammomium bromide; potassium hydroxide; In dichloromethane; water; at 0 ℃; for 1h;

Reference yield: 79.0%

: 79762-54-2
6-bromo-1H-indazole

: 2-(trimethylsilyl)ethoxy chloride

: 894808-02-7
6-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

Reference yield:

: 894808-02-7
6-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole

: 744219-43-0
tert-butyl 4-( 1H-indazol-6-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 105 °C / Inert atmosphere

2.1: hydrogenchloride / water; methanol / 1 h / 20 °C

2.2: 2 h

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In methanol; water; toluene;