Technology Process of 4-BROMO-6-INDOLECARBOXYLIC ACID
There total 1 articles about 4-BROMO-6-INDOLECARBOXYLIC ACID which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 4-bromo-1H-indole-6-carboxylate;
With
methanol; sodium hydroxide; water;
at 20 ℃;
for 2.5h;
With
hydrogenchloride;
In
water;
- Guidance literature:
-
4-bromo-1H-indole-6-carboxylic acid;
In
N,N-dimethyl-formamide; mineral oil;
at 0 ℃;
for 0.25h;
p-toluenesulfonyl chloride;
In
N,N-dimethyl-formamide; mineral oil;
at 0 - 10 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 16 h / 20 °C
2: trifluoroacetic acid; triethylsilane / 4 h / 0 °C
3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C
4: tetrakis(triphenylphosphine) palladium(0); caesium carbonate / water; 1,4-dioxane / 16 h / 100 °C / Inert atmosphere
5: hydrogenchloride / ethyl acetate / 2 h / 20 °C
6: sodium hydrogencarbonate / ethanol / 16 h / 20 °C
With
hydrogenchloride; triethylsilane; tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid;
In
1,4-dioxane; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
