2(1H)-Quinazolinone (6CI,8CI,9CI)

Base Information

• Chemical Name: 2(1H)-Quinazolinone (6CI,8CI,9CI)
• CAS No.: 7471-58-1
• Molecular Formula: C8H6N2O
• Molecular Weight: 146.148
• Hs Code.: 2933990090
• Mol file: 7471-58-1.mol

Synonyms:1H-quinazolin-2-one;2-Quinoxalone;3-(Chloromethyl)-6-(Trifluoromethyl)Pyridine;2-Quinazolinol;2-Quinazolinone;2 (1H)-Quinazolinone;

Chemical Property of 2(1H)-Quinazolinone (6CI,8CI,9CI)

Chemical Property:

• Vapor Pressure: 8.33E-07mmHg at 25°C
• Melting Point: 250 °C
• Refractive Index: 1.666
• Boiling Point: 395 °Cat760mmHg
• PKA: 12.40±0.20(Predicted)
• Flash Point: 192.7 °C
• PSA: 45.75000
• Density: 1.31 g/cm³
• LogP: 0.92310
• Storage Temp.: 2-8°C

Purity/Quality:

99.5% ^*data from raw suppliers

Quinazolin-2-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2(1H)-Quinazolinone (6CI,8CI,9CI)

There total 1 articles about 2(1H)-Quinazolinone (6CI,8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ quinazolin-2-one (7471-58-1) + diethyl ether (60-29-7,927820-24-4)

Guidance literature:

Reference yield: 87.0%

1-(1-(4-methoxyphenyl)ethylidene)-2-tosylhydrazine (32117-52-5) + 2-hydroxyquinazoline (7471-58-1) → C17H14N2O

Guidance literature:

2-hydroxyquinazoline; With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In 1,4-dioxane; at 25 ℃; for 2h; Inert atmosphere;

1-(1-(4-methoxyphenyl)ethylidene)-2-tosylhydrazine; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; t-BuBrettPhos; caesium carbonate; In 1,4-dioxane; for 2h; Inert atmosphere; Heating;

DOI:10.1016/j.tetlet.2015.10.022

Reference yield:

quinazolin-2-one (7471-58-1) + 2-Phenoxyethanol (122-99-6,56257-90-0,9004-78-8) + Phosphoroxy chloride → quinazoline (253-82-7)

Guidance literature:

With sodium hydroxide; tetrabutylammomium bromide; In methanol; toluene;

Downstream raw materials:

2-(2'-hydroxyphenyl)-4-(3H)-quinazolinone

4(3H)-oxo-6-(bromomethyl)-2-methyl quinazoline

quinazoline

6-Acetyl-4-ethyl-3,4-dihydro-3-methyl-4-phenylquinazolin-2(1H)-one

Refernces