C-(2-Trifluoromethyl-pyridin-4-yl)-methylamine

Base Information

• Chemical Name: C-(2-Trifluoromethyl-pyridin-4-yl)-methylamine
• CAS No.: 916304-20-6
• Molecular Formula: C7H7F3N2
• Molecular Weight: 176.13900
• Hs Code.: 2933399990
• Mol file: 916304-20-6.mol

Synonyms:QC-3004;

Chemical Property of C-(2-Trifluoromethyl-pyridin-4-yl)-methylamine

Chemical Property:

• Vapor Pressure: 0.375mmHg at 25°C
• Boiling Point: 197.6oC at 760 mmHg
• Flash Point: 73.3oC
• PSA: 38.91000
• Density: 1.293g/cm3
• LogP: 2.25940
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(2-(trifluoromethyl)pyridin-4-yl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of C-(2-Trifluoromethyl-pyridin-4-yl)-methylamine

There total 5 articles about C-(2-Trifluoromethyl-pyridin-4-yl)-methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(azidomethyl)-2-(trifluoromethyl)pyridine → 2-trifluoromethyl-4-(aminomethyl)pyridine (916304-20-6)

Guidance literature:

With tin(II) chloride dihdyrate; In methanol; at 0 - 20 ℃; for 3h;

Reference yield:

<2-(trifluoromethyl)pyridin-4-yl>methanol (131747-61-0) → 2-trifluoromethyl-4-(aminomethyl)pyridine (916304-20-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; methanesulfonyl chloride / dichloromethane / 1 h / 0 °C

1.2: 20 °C

2.1: tin(II) chloride dihdyrate / methanol / 3 h / 0 - 20 °C

With tin(II) chloride dihdyrate; methanesulfonyl chloride; triethylamine; In methanol; dichloromethane;

Reference yield:

(2-(trifluoromethyl)pyridin-4-yl)methyl methanesulfonate → 2-trifluoromethyl-4-(aminomethyl)pyridine (916304-20-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 20 °C

2: tin(II) chloride dihdyrate / methanol / 2 h / 20 °C

With sodium azide; tin(II) chloride dihdyrate; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

<2-(trifluoromethyl)pyridin-4-yl>methanol

2-trifluoromethyl-isonicotinic acid methyl ester

4-bromo-2-(trifluoromethyl)pyridine

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