Technology Process of 1H-Pyrrolo[3,2-b]pyridine-5-methanol
There total 4 articles about 1H-Pyrrolo[3,2-b]pyridine-5-methanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 ℃;
for 2h;
Inert atmosphere;
DOI:10.1021/acs.jmedchem.5b01240
- Guidance literature:
-
Multi-step reaction with 4 steps
1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 22 - 26 °C
2: pyridine / dichloromethane / 2 h / 0 - 26 °C
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 8 h / Reflux
4: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C
With
pyridine; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; triethylamine;
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide;
In
tetrahydrofuran; dichloromethane;
1: Sonogashira Coupling;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: pyridine / dichloromethane / 2 h / 0 - 26 °C
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 8 h / Reflux
3: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C
With
pyridine; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride;
In
tetrahydrofuran; dichloromethane;
