Technology Process of 13-methylberberrubine
There total 4 articles about 13-methylberberrubine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C28H27NO6;
With
methanesulfonyl chloride; triethylamine;
In
dichloromethane;
at 20 ℃;
for 6h;
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / tetrahydrofuran / 65 °C
2.1: sodium carbonate; tris-(dibenzylideneacetone)dipalladium(0); XPhos / toluene; ethanol / 12 h / 110 °C / Inert atmosphere
3.1: triethylamine; methanesulfonyl chloride / dichloromethane / 6 h / 20 °C
3.2: 2 h / 20 °C
With
tris-(dibenzylideneacetone)dipalladium(0); tetra-(n-butyl)ammonium iodide; sodium carbonate; potassium carbonate; methanesulfonyl chloride; triethylamine; XPhos;
In
tetrahydrofuran; ethanol; dichloromethane; toluene;
