Technology Process of 1H-Pyrazolo[4,3-b]pyridine-6-carboxylicacid
There total 8 articles about 1H-Pyrazolo[4,3-b]pyridine-6-carboxylicacid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1H-pyrazolo[4,3-b]pyridine-6-carboxylic acid methyl ester;
With
water; sodium hydroxide;
In
methanol;
at 0 - 20 ℃;
With
hydrogenchloride;
In
water;
pH=5 - 6;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C
1.2: 2 h / 100 °C
2.1: hydrogenchloride; water / 18 h / Reflux
2.2: 0 °C
3.1: hydrogenchloride; iron / ethanol; water / 40 °C / Reflux
4.1: triethylamine / dichloromethane / 0 - 20 °C
5.1: acetic anhydride; potassium acetate; acetic acid / chloroform / 0.25 h / 20 °C
5.2: 40 - 60 °C
5.3: 0 - 20 °C
6.1: triethylamine / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium dichloride / acetonitrile / 18 h / 100 °C / 15001.5 Torr
7.1: sodium hydroxide; water / methanol / 0 - 20 °C
7.2: pH 5 - 6
With
hydrogenchloride; water; potassium acetate; acetic anhydride; iron; sodium hydride; acetic acid; triethylamine; sodium hydroxide;
2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium dichloride;
In
methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogenchloride; iron / ethanol; water / 40 °C / Reflux
2.1: triethylamine / dichloromethane / 0 - 20 °C
3.1: acetic anhydride; potassium acetate; acetic acid / chloroform / 0.25 h / 20 °C
3.2: 40 - 60 °C
3.3: 0 - 20 °C
4.1: triethylamine / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium dichloride / acetonitrile / 18 h / 100 °C / 15001.5 Torr
5.1: sodium hydroxide; water / methanol / 0 - 20 °C
5.2: pH 5 - 6
With
hydrogenchloride; water; potassium acetate; acetic anhydride; iron; acetic acid; triethylamine; sodium hydroxide;
2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium dichloride;
In
methanol; ethanol; dichloromethane; chloroform; water; acetonitrile;
