Limaprost alfadex

Base Information

Chemical Name:Limaprost alfadex
CAS No.:88852-12-4
Deprecated CAS:114868-77-8
Molecular Formula:C57H94O35
Molecular Weight:1353.36
Hs Code.:
European Community (EC) Number:832-042-8
Mol file:88852-12-4.mol

Synonyms:limaprost-alfadex;limaprost-alpha-cyclodextrin complex;Opalmon

Suppliers and Price of Limaprost alfadex

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
LIMAPROST ALFADEX 98.00%
10MG
$ 945.95

Total 19 raw suppliers

Chemical Property of Limaprost alfadex

Chemical Property:

PSA：569.73000
LogP:-9.16760
Hydrogen Bond Donor Count:21
Hydrogen Bond Acceptor Count:35
Rotatable Bond Count:18
Exact Mass:1338.5575647
Heavy Atom Count:92
Complexity:1740

Purity/Quality:

99%, ^*data from raw suppliers

LIMAPROST ALFADEX 98.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCC(C)CC(C=CC1C(CC(=O)C1CCCC=CC(=O)O)O)O.C(C1C2C(C(C(O1)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)OC5C(OC(C(C5O)O)OC6C(OC(C(C6O)O)OC7C(OC(O2)C(C7O)O)CO)CO)CO)CO)CO)O)O)O
Isomeric SMILES:CCCC[C@H](C)C[C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1CCC/C=C\C(=O)O)O)O.C([C@@H]1[C@@H]2[C@@H]([C@H]([C@H](O1)O[C@@H]3[C@H](O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]4[C@H](O[C@@H]([C@@H]([C@H]4O)O)O[C@@H]5[C@H](O[C@@H]([C@@H]([C@H]5O)O)O[C@@H]6[C@H](O[C@@H]([C@@H]([C@H]6O)O)O[C@@H]7[C@H](O[C@H](O2)[C@@H]([C@H]7O)O)CO)CO)CO)CO)CO)O)O)O
Recent NIPH Clinical Trials:Clinical effect of NTN tablets on lumbar spinal canal stenosis with low back pain
Description Limaprost is an orally-active antithrombotic and vasodilator structurally related to alprostadil. Oral administration of limaprost causes a dose-dependent inhibition of platelet aggregation, an increase in platelet CAMP and a mild suppression of platelet adhesiveness. In patients with pulmonary emphysema, tuberculosis, and chronic lung disease, treatment with limaprost reportedly produces significant cardiac improvements.
Uses Limaprost Alfadex is used in the sysnthesis of prostaglandins and its derivatives.

Technology Process of Limaprost alfadex

There total 28 articles about Limaprost alfadex which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: (E)-7-{(1R,2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(3S,5S)-3-(tert-butyl-dimethyl-silanyloxy)-5-methyl-non-1-enyl]-5-oxo-cyclopentyl}-hept-2-enoic acid

: 88852-12-4,114868-74-5,75554-85-7,114868-76-7
limaprost

Guidance literature:: With hydrogen fluoride; In acetonitrile;
DOI:10.1246/cl.1992.2095

Reference yield:

: C₃₂H₅₂O₇

: 88852-12-4,114868-74-5,75554-85-7,114868-76-7
limaprost

Guidance literature:: With acetic acid; In tetrahydrofuran; water; at 80 ℃; for 0.5h;

Reference yield:

: 144877-58-7
(E)-7-{(1R,2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(E)-(3S,5S)-3-(tert-butyl-dimethyl-silanyloxy)-5-methyl-non-1-enyl]-5-oxo-cyclopentyl}-hept-2-enoic acid allyl ester

: 88852-12-4,114868-74-5,75554-85-7,114868-76-7
limaprost

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / HCO₂H, Et₃N, Pd₂(dibenzylidene)3*CHCl₃ / 2 h / 40 °C

2: 73 percent / aq. HF / acetonitrile

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; formic acid; hydrogen fluoride; triethylamine; In acetonitrile;
DOI:10.1246/cl.1992.2095