Chemical Property of Sulfaphenazole
Chemical Property:
- Vapor Pressure:8.34E-12mmHg at 25°C
- Melting Point:179-183 °C
- Refractive Index:1.6440 (estimate)
- Boiling Point:541.9°Cat760mmHg
- PKA:pKa 5.71(H2O
t = 25
I = 0.05) (Uncertain)
- Flash Point:281.5°C
- PSA：98.39000
- Density:1.39g/cm3
- LogP:3.99030
- Storage Temp.:2-8°C
- Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- XLogP3:1.5
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:4
- Exact Mass:314.08374688
- Heavy Atom Count:22
- Complexity:451
- Purity/Quality:
-
99%, *data from raw suppliers
Trefoil Factor 2 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
24/25
- MSDS Files:
-
SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:C1=CC=C(C=C1)N2C(=CC=N2)NS(=O)(=O)C3=CC=C(C=C3)N
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Description
CYP2C9 is a major cytochrome P450 enzyme that is involved in the metabolic clearance of various therapeutic agents. Disruption of this enzyme’s activity can lead to adverse drug reactions. Sulfaphenazole is an inhibitor of CYP2C9 (Ki = 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Kis = 63 and 29 μM for CYP2C8 and CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19). At 10 μM, sulfaphenazole has been shown to inhibit endothelium-derived hyperpolarizing factor synthase, a CYP450 isozyme in the porcine coronary artery homologous to CYP2C8/9 that generates reactive oxygen species in coronary endothelial cells and modulates vascular tone and homeostasis.
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Uses
Sulfaphenazole is used as an inhibitor for mammalian CYP2C9, an enzyme of the cytochrome P450 family allowing for pharmacological application.
Sulfaphenazole can help protect against ischemia-reperfus
ion, and resulting tissue damage by inhibition of CYP2C9. Sulfaphenazole has been used as a positive control to inhibit cytochrome P450 2C9 (cyp2c9) to quantify Rhodiola rosea inhibition. It has also been used as cytochrome P450 2C9 (cyp2c9) inhibitor in endothelial cells and microsomal preparations. Sulfaphenazole is used as an inhibitor for mammalian CYP2C9, an enzyme of the cytochrome P450 family allowing for pharmacological application.Sulfaphenazole can help protect against ischemia-reperfusion, and resulting tissue damage by inhibition of CYP2C9.
