(-)-3-Hydroxy-4-(tetrahydro-2,6,6-trimethyl-2H-pyran-2-yl)benzoic acid

Base Information

Chemical Name:(-)-3-Hydroxy-4-(tetrahydro-2,6,6-trimethyl-2H-pyran-2-yl)benzoic acid
CAS No.:55708-43-5
Molecular Formula:C₁₅H₂₀O₄
Molecular Weight:264.321
Hs Code.:
Mol file:55708-43-5.mol

Synonyms:sydowic acid;3-Hydroxy-4-((S)-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-benzoic acid;

Suppliers and Price of (-)-3-Hydroxy-4-(tetrahydro-2,6,6-trimethyl-2H-pyran-2-yl)benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 3 raw suppliers

Chemical Property of (-)-3-Hydroxy-4-(tetrahydro-2,6,6-trimethyl-2H-pyran-2-yl)benzoic acid

Chemical Property:

PSA：66.76000
LogP:3.28470

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of (-)-3-Hydroxy-4-(tetrahydro-2,6,6-trimethyl-2H-pyran-2-yl)benzoic acid

There total 8 articles about (-)-3-Hydroxy-4-(tetrahydro-2,6,6-trimethyl-2H-pyran-2-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 120342-11-2
(R)-(2-t-butyldimethylsilyloxy-4-methyl)phenyl (p-tolylsulfinyl)methyl ketone

: 55708-43-5
(S)-(-)-sydowic acid

Guidance literature:: Multi-step reaction with 8 steps

1: toluene / 13.5 h

2: 67 percent / Zn, trimethylsilyl chloride

3: 1.) trimethyloxonium fluoroborate; 2.) aq. NaOH

4: 52 percent / CuI

5: 73 percent / 50percent H₂SO₄

6: pyridine

7: KMnO₄

8: KOH

With pyridine; potassium hydroxide; sodium hydroxide; potassium permanganate; chloro-trimethyl-silane; sulfuric acid; trimethoxonium tetrafluoroborate; zinc; copper(l) iodide; In toluene;
DOI:10.1246/cl.1988.1541

Reference yield:

: 120342-20-3
tert-Butyl-dimethyl-[5-methyl-2-((R)-2-methyl-oxiranyl)-phenoxy]-silane

: 55708-43-5
(S)-(-)-sydowic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 52 percent / CuI

2: 73 percent / 50percent H₂SO₄

3: pyridine

4: KMnO₄

5: KOH

With pyridine; potassium hydroxide; potassium permanganate; sulfuric acid; copper(l) iodide;
DOI:10.1246/cl.1988.1541

Reference yield:

: 120342-19-0
(R)-2-[2-(tert-Butyl-dimethyl-silanyloxy)-4-methyl-phenyl]-1-p-tolylsulfanyl-propan-2-ol

: 55708-43-5
(S)-(-)-sydowic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) trimethyloxonium fluoroborate; 2.) aq. NaOH

2: 52 percent / CuI

3: 73 percent / 50percent H₂SO₄

4: pyridine

5: KMnO₄

6: KOH

With pyridine; potassium hydroxide; sodium hydroxide; potassium permanganate; sulfuric acid; trimethoxonium tetrafluoroborate; copper(l) iodide;
DOI:10.1246/cl.1988.1541