Imidazo[1,2-a]pyridine-8-carboxylic acid, 2-(trifluoromethyl)-, ethyl ester

Base Information

Chemical Name:Imidazo[1,2-a]pyridine-8-carboxylic acid, 2-(trifluoromethyl)-, ethyl ester
CAS No.:133427-48-2
Molecular Formula:C11H9F3N2O2
Molecular Weight:258.19700
Hs Code.:
Mol file:133427-48-2.mol

Synonyms:Ethyl (2-trifluoromethylimidazo[1,2-a]pyridin-8-yl)carboxylate;

Suppliers and Price of Imidazo[1,2-a]pyridine-8-carboxylic acid, 2-(trifluoromethyl)-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of Imidazo[1,2-a]pyridine-8-carboxylic acid, 2-(trifluoromethyl)-, ethyl ester

Chemical Property:

PKA:6.04±0.50(Predicted)
PSA：43.60000
Density:1.39±0.1 g/cm3(Predicted)
LogP:2.52980

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Imidazo[1,2-a]pyridine-8-carboxylic acid, 2-(trifluoromethyl)-, ethyl ester

There total 2 articles about Imidazo[1,2-a]pyridine-8-carboxylic acid, 2-(trifluoromethyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 13362-26-0
2-aminopyridine-3-carboxylic acid ethyl ester

: 431-35-6
3-bromo-1,1,1-trifluoroacetone

: 133427-48-2
ethyl 2-trifluoromethylimidazo[1,2-a]pyridine-8-carboxylate

Guidance literature:: 2-aminopyridine-3-carboxylic acid ethyl ester; 3-bromo-1,1,1-trifluoroacetone; In ethanol; for 90h; Inert atmosphere; Reflux;

With sodium hydrogencarbonate; In water;
DOI:10.1016/j.ejmech.2010.01.023

Reference yield: 67.0%

: 133427-48-2
ethyl 2-trifluoromethylimidazo[1,2-a]pyridine-8-carboxylate

Guidance literature:

Reference yield: 54.0%

: 133427-48-2
ethyl 2-trifluoromethylimidazo[1,2-a]pyridine-8-carboxylate

: 167884-04-0
8-hydroxymethyl-2-(trifluoromethyl)imidazo[1,2-a]pyridine

Guidance literature:: ethyl 2-trifluoromethylimidazo[1,2-a]pyridine-8-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 3.5h; Inert atmosphere;

With water; sodium hydroxide; In tetrahydrofuran;
DOI:10.1016/j.ejmech.2010.01.023