2-(3-FLUOROPHENYL)-1H-INDOLE

Base Information

• Chemical Name: 2-(3-FLUOROPHENYL)-1H-INDOLE
• CAS No.: 124643-63-6
• Molecular Formula: C₁₄H₁₀FN
• Molecular Weight: 211.239
• Mol file: 124643-63-6.mol

Synonyms:

Chemical Property of 2-(3-FLUOROPHENYL)-1H-INDOLE

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

1H-INDOLE,2-(3-FLUOROPHENYL)- 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-FLUOROPHENYL)-1H-INDOLE

There total 18 articles about 2-(3-FLUOROPHENYL)-1H-INDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-(3-fluorophenyl)-2-(phenylamino)ethanone + aniline (62-53-3) → 2-(3-fluorophenyl)-1H-indole (124643-63-6)

Guidance literature:

1-(3-fluorophenyl)-2-(phenylamino)ethanone; aniline; With triphenylphosphine; palladium(II) bromide; In 2,2,2-trifluoroethanol; toluene; for 0.25h; Schlenk technique; Inert atmosphere;

With hydrogen; sodium sulfate; In 2,2,2-trifluoroethanol; toluene; at 150 ℃; for 24h; under 41372.9 Torr; regioselective reaction; Autoclave; Schlenk technique;

DOI:10.1002/ejoc.201900394

Reference yield: 91.0%

C14H10FN3 (1054567-09-7) → 2-(3-fluorophenyl)-1H-indole (124643-63-6)

Guidance literature:

With rhodium(II) perfluorobutyrate dimer; In toluene; at 60 ℃; for 16h; Molecular sieve;

DOI:10.1002/anie.200800689

Reference yield: 77.0%

indole (120-72-9) + 3-fluorophenylboronic acid (768-35-4) → 2-(3-fluorophenyl)-1H-indole (124643-63-6)

Guidance literature:

With oxygen; palladium diacetate; In acetic acid; at 20 ℃;

DOI:10.1021/acs.jmedchem.9b01142

upstream raw materials:

2-((3-fluorophenyl)ethynyl)aniline

2-ethynylaniline

1-Fluoro-3-iodobenzene

2-iodophenylamine

Downstream raw materials:

C₂₃H₂₀FNO₃S

C₂₄H₂₀FNO₄

2-(meta-fluoro)phenylquinazolin-4(3H)-one

(S)-N(α)-acetyl-2-(3-fluorophenyl)tryptophan methyl ester

Refernces

• 1、 Garai, Sumanta,Kulkarni, Pushkar M.,Schaffer, Peter C.,Leo, Luciana M.,Brandt, Asher L.,Zagzoog, Ayat,Black, Tallan,Lin, Xiaoyan,Hurst, Dow P.,Janero, David R.,Abood, Mary E.,Zimmowitch, Anaelle,Straiker, Alex,Pertwee, Roger G.,Kelly, Melanie,Szczesniak, Anna-Maria,Denovan-Wright, Eileen M.,Mackie, Ken,Hohmann, Andrea G.,Reggio, Patricia H.,Laprairie, Robert B.,Thakur, Ganesh A.. "Application of Fluorine- And Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators". . p. 542 - 568. Retrieved 2020/02/04.
• 2、 Banerjee, Isita,Ghosh, Keshab Ch,Sinha, Surajit. "Pd-catalyzed C–H bond activation of Indoles for Suzuki reaction". . . Retrieved 2019/08/22.