Technology Process of ethyl 5-aMino-2-broMothiazole-4-carboxylate
There total 4 articles about ethyl 5-aMino-2-broMothiazole-4-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-Bromosuccinimide;
In
acetonitrile;
at 20 ℃;
for 0.5h;
DOI:10.1002/jhet.4452
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium nitrite; phosphoric acid / water
2.1: sodium hydrogencarbonate; sodium dithionite / water / 2 h / 35 °C
3.1: acetic anhydride / 2 h / 55 °C
3.2: 8 h / 0 - 20 °C
4.1: Lawessons reagent / toluene / 12 h / Inert atmosphere; Reflux
5.1: N-Bromosuccinimide / acetonitrile / 0.5 h / 20 °C
With
Lawessons reagent; N-Bromosuccinimide; sodium dithionite; phosphoric acid; acetic anhydride; sodium hydrogencarbonate; sodium nitrite;
In
water; toluene; acetonitrile;
DOI:10.1002/jhet.4452
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydrogencarbonate; sodium dithionite / water / 2 h / 35 °C
2.1: acetic anhydride / 2 h / 55 °C
2.2: 8 h / 0 - 20 °C
3.1: Lawessons reagent / toluene / 12 h / Inert atmosphere; Reflux
4.1: N-Bromosuccinimide / acetonitrile / 0.5 h / 20 °C
With
Lawessons reagent; N-Bromosuccinimide; sodium dithionite; acetic anhydride; sodium hydrogencarbonate;
In
water; toluene; acetonitrile;
DOI:10.1002/jhet.4452
