2,3-difluoroisonicotinonitrile

Base Information

• Chemical Name: 2,3-difluoroisonicotinonitrile
• CAS No.: 1210041-67-0
• Molecular Formula: C6H2F2N2
• Molecular Weight: 140.09
• Mol file: 1210041-67-0.mol

Synonyms:2,3-difluoropyridine-4-carbonitrile;

Chemical Property of 2,3-difluoroisonicotinonitrile

Chemical Property:

• PSA: 36.68000
• LogP: 1.23148
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2,3-Difluoro-isonicotinonitrile 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-difluoroisonicotinonitrile

There total 3 articles about 2,3-difluoroisonicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,3-difluoro-4-iodopyridine (851386-34-0) + copper(l) cyanide → 2,3-difluoroisonicotinonitrile (1210041-67-0)

Guidance literature:

In propiononitrile; at 160 ℃; for 3.5h; regioselective reaction; Microwave irradiation;

DOI:10.1055/s-0029-1217084

Reference yield:

2,3-difluoropyridine-4-carboxylic acid (851386-31-7) → 2,3-difluoroisonicotinonitrile (1210041-67-0)

Guidance literature:

With triethylamine; trifluoroacetic anhydride; In dichloromethane; at 15 ℃; for 17h;

Reference yield:

2,3-difluoroisonicotinamide → 2,3-difluoroisonicotinonitrile (1210041-67-0)

Guidance literature:

With triethylamine; trifluoroacetic anhydride; In dichloromethane; at 15 ℃; for 17h;

upstream raw materials:

2,3-difluoro-4-iodopyridine

2,3-difluoropyridine-4-carboxylic acid

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