2-Azetidinone, 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-[4-(phenylmethox y)phenyl]-, (3R,4S)-rel-

Base Information

• Chemical Name: 2-Azetidinone, 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-[4-(phenylmethox y)phenyl]-, (3R,4S)-rel-
• CAS No.: 928045-10-7
• Molecular Formula: C₃₁H₂₅F₂NO₃
• Molecular Weight: 497.541

Synonyms:2-Azetidinone, 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-[4-(phenylMethox y)phenyl]-, (3R,4S)-rel-

Chemical Property of 2-Azetidinone, 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-[4-(phenylmethox y)phenyl]-, (3R,4S)-rel-

Chemical Property:

• Boiling Point: 706.8±60.0 °C (760 mmHg)
• PSA: 46.61000
• Density: 1.264±0.06 g/cm3 (20 °C, 760 mmHg)
• LogP: 6.97600

Purity/Quality:

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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Azetidinone, 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-[4-(phenylmethox y)phenyl]-, (3R,4S)-rel-

There total 51 articles about 2-Azetidinone, 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-[4-(phenylmethox y)phenyl]-, (3R,4S)-rel- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(3R,4S)-4-(4-benzyloxyphenyl)-1-(4-fluoro phenyl)-3-{2-[2-(4-fluorophenyl)-[1,3]-dioxolan-2-yl]ethyl}azetidin-2-one (954109-22-9) → (3R,4S)-4-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one (190595-65-4,928045-10-7)

Guidance literature:

With water; toluene-4-sulfonic acid; In acetone; at 20 ℃; for 6h; Product distribution / selectivity; Reflux;

Reference yield: 91.6%

(S)-ethyl 2-((4-(benzyloxy)phenyl)(4-fluorophenylamino)methyl)-5-(4-fluorophenyl)-5-oxopentanoate → (3R,4S)-4-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one (190595-65-4,928045-10-7)

Guidance literature:

at 20 ℃; for 0.166667h; Temperature;

Reference yield: 90.0%

4(S)-(4-benzyloxyphenyl)-1-(4-fluorophenyl)-3(R)-{2-[2-(4-fluorophenyI)-5,5-dimethyl-[1,3]-dioxan-2-yl]-ethyl}azetidine-2-one (953805-24-8) → (3R,4S)-4-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one (190595-65-4,928045-10-7)

Guidance literature:

With formic acid; In dichloromethane; for 12h; Reflux;

upstream raw materials:

4-fluorophenylzinc bromide

3-((3R,4S)-1-(4-fluorophenyl)-2-oxo-4-(4-(benzyloxy)phenyl)azetidin-3-yl)propionic acid chloride

(3R,4S)-4-(4-Benzyloxy-phenyl)-1-(4-fluoro-phenyl)-3-[(E)-3-(4-fluoro-phenyl)-3-oxo-propenyl]-azetidin-2-one

4(S)-(4-benzyloxyphenyl)-1-(4-fluorophenyl)-3(R)-{2-[2-(4-fluorophenyI)-5,5-dimethyl-[1,3]-dioxan-2-yl]-ethyl}azetidine-2-one

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