(S)-(4-benzylmorpholin-2-yl)methanamine

Base Information

• Chemical Name: (S)-(4-benzylmorpholin-2-yl)methanamine
• CAS No.: 186293-55-0
• Molecular Formula: C12H18N2O
• Molecular Weight: 206.288
• DSSTox Substance ID: DTXSID90426134
• Wikidata: Q82239101
• Mol file: 186293-55-0.mol

Synonyms:(S)-(4-benzylmorpholin-2-yl)methanamine;186293-55-0;[(2S)-4-benzylmorpholin-2-yl]methanamine;(S)-4-Benzyl-2-(aminomethyl)morpholine;2-Morpholinemethanamine, 4-(phenylmethyl)-, (S)-;SCHEMBL1759405;DTXSID90426134;(S)-(4-Benzylmorpholin-2-yl)methanamine;(S)-2-(Aminomethyl)-4-benzylmorpholine;CKZVBXBEDDAEFE-LBPRGKRZSA-N;CS-B1646;MFCD18632720;(S)-2-aminomethyl-4-benzylmorpholine;AKOS016843528;SS-4885;1-[(2S)-4-benzylmorpholin-2-yl]methanamine;A813021

Chemical Property of (S)-(4-benzylmorpholin-2-yl)methanamine

Chemical Property:

• PSA: 38.49000
• LogP: 1.48430
• Storage Temp.: 2-8°C
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 206.141913202
• Heavy Atom Count: 15
• Complexity: 181

Purity/Quality:

97% ^*data from raw suppliers

[(2S)-4-Benzylmorpholin-2-yl]methanamine 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(CN1CC2=CC=CC=C2)CN
• Isomeric SMILES: C1CO[C@H](CN1CC2=CC=CC=C2)CN

Technology Process of (S)-(4-benzylmorpholin-2-yl)methanamine

There total 3 articles about (S)-(4-benzylmorpholin-2-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-benzylmorpholin-2-yl)methanamine (110859-47-7,140646-11-3) → (S)-(4-benzylmorpholin-2-yl)methanamine (186293-55-0)

Guidance literature:

DOI:10.1016/S0960-894X(98)00390-4

Reference yield:

4-benzyl-2-cyanomorpholine (147767-51-9,126645-52-1) → (S)-(4-benzylmorpholin-2-yl)methanamine (186293-55-0)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

2: rac-tartaric acid dibenzoate / ethanol; water / 20 °C

With lithium aluminium tetrahydride; rac-tartaric acid dibenzoate; In tetrahydrofuran; ethanol; water;

DOI:10.1016/j.bmcl.2012.06.079

Reference yield:

→ (S)-(4-benzylmorpholin-2-yl)methanamine (186293-55-0)

Guidance literature:

upstream raw materials:

(4-benzylmorpholin-2-yl)methanamine

4-benzyl-2-cyanomorpholine

Downstream raw materials:

(R)-N,N-dimethyl-1-(morpholin-2-yl)methanamine

(S)-1-cyclopropyl-1,4-dihydro-7-[2-(N,N-dimethylaminomethyl)morpholino]-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid

(S)-4-benzyl-2-(N,N-dimethylaminomethyl)morpholine

N₄-{[(2S)-4-benzylmorpholin-2-yl]methyl}-6-chloro-2-cyclopropylpyrimidine-4,5-diamine

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