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MonoMethyl auristatin E

Base Information Edit
  • Chemical Name:MonoMethyl auristatin E
  • CAS No.:474645-27-7
  • Molecular Formula:C39H67N5O7
  • Molecular Weight:717.99
  • Hs Code.:
  • European Community (EC) Number:811-424-8
  • UNII:V7I58RC5EJ
  • ChEMBL ID:CHEMBL2103835
  • DSSTox Substance ID:DTXSID101028844
  • NCI Thesaurus Code:C122637
  • Nikkaji Number:J1.915.648F
  • Wikidata:Q6901739
  • Wikipedia:Monomethyl_auristatin_E
  • Mol file:474645-27-7.mol
MonoMethyl auristatin E

Synonyms:MMAE

Suppliers and Price of MonoMethyl auristatin E
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • MMAE
  • 100mg
  • $ 910.00
  • Matrix Scientific
  • (S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1R,2R)-1-Hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxohe 97%
  • 50mg
  • $ 1728.00
  • Matrix Scientific
  • (S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1R,2R)-1-Hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxohe 97%
  • 100mg
  • $ 2700.00
  • DC Chemicals
  • MonomethylauristatinE(vedotin)
  • 003
  • $ 1800.00
  • DC Chemicals
  • MonomethylauristatinE(vedotin)
  • 002
  • $ 900.00
  • DC Chemicals
  • MonomethylauristatinE(vedotin)
  • 001
  • $ 500.00
  • Crysdot
  • Vedotin 97%
  • 25mg
  • $ 500.00
  • Crysdot
  • Vedotin 97%
  • 10mg
  • $ 340.00
  • ChemScene
  • MonomethylauristatinE 99.92%
  • 1g
  • $ 960.00
  • ChemScene
  • MonomethylauristatinE 99.92%
  • 5g
  • $ 3260.00
Total 125 raw suppliers
Chemical Property of MonoMethyl auristatin E Edit
Chemical Property:
  • Boiling Point:873.5±65.0 °C(Predicted) 
  • PKA:13.66±0.20(Predicted) 
  • PSA:149.54000 
  • Density:1.088±0.06 g/cm3(Predicted) 
  • LogP:4.64040 
  • Storage Temp.:-20°C Freezer 
  • Solubility.:DMSO (Slightly), Methanol (Slightly, Sonicated) 
  • XLogP3:4.1
  • Hydrogen Bond Donor Count:4
  • Hydrogen Bond Acceptor Count:8
  • Rotatable Bond Count:20
  • Exact Mass:717.50404949
  • Heavy Atom Count:51
  • Complexity:1100
Purity/Quality:

97% *data from raw suppliers

MMAE *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CCC(C)C(C(CC(=O)N1CCCC1C(C(C)C(=O)NC(C)C(C2=CC=CC=C2)O)OC)OC)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)NC
  • Isomeric SMILES:CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@H](C)[C@H](C2=CC=CC=C2)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC
  • Description MMAE is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. Monomethyl auristatin E or MMAE is 100-1000 times more potent than doxorubicin. It is a very potent antimitotic agent that inhibits cell division by blocking the polymerization of tubulin.
  • Uses MMAE is an effective and synthetic cytotoxic analog of Dolastatin 10 which is a potent antimitotic polypeptide isolated from a marine animal. Dolastatin 10 is a natural antimitotic and antineoplastic agent that binds to tubulin and inhibits tubulin polymerization. Monomethyl Auristatin E (MMAE) is a synthetic analog of dolastatin 10 that similarly inhibits tubulin polymerization and exhibits potent cytotoxicity. It is commonly conjugated with monoclonal antibodies directed at antigens specific to cancer cells for tumor-directed cytotoxicity. MMAE is typically coupled to the antibody via a protease-cleavable linker, allowing separation of the drug from the antibody following intracellular localization.[Cayman Chemical]
Technology Process of MonoMethyl auristatin E

There total 40 articles about MonoMethyl auristatin E which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With hydrogenchloride; In 1,4-dioxane; toluene; at 20 ℃; for 16h;
Guidance literature:
In dichloromethane;
Guidance literature:
With diethylamine; In dichloromethane; at 20 ℃;
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