tert-Butyl ((1H-indol-3-yl)methyl)carbamate

Base Information

Chemical Name:tert-Butyl ((1H-indol-3-yl)methyl)carbamate
CAS No.:60524-00-7
Molecular Formula:C14H18N2O2
Molecular Weight:246.3
Hs Code.:2933990090
DSSTox Substance ID:DTXSID40500675
Wikidata:Q82352481
Mol file:60524-00-7.mol

Synonyms:60524-00-7;tert-Butyl ((1H-indol-3-yl)methyl)carbamate;(1H-Indol-3-ylmethyl)carbamic acid tert-butyl ester;tert-butyl N-(1H-indol-3-ylmethyl)carbamate;tert-butyl (1H-indol-3-yl)methylcarbamate;(1H-lndol-3-ylmethyl)-carbamic acid tert-butyl ester;tert-Butyl [(1H-indol-3-yl)methyl]carbamate;SCHEMBL19100705;DTXSID40500675;AB6708;MFCD12405320;AKOS015838159;DS-0231;tert-butyl (1H-indol-3-ylmethyl)carbamate;BB 0248300;FT-0735535;tert-butyl N-[(1H-indol-3-yl)methyl]carbamate;A868959;2-Methyl-2-propanyl (1H-indol-3-ylmethyl)carbamate;J-524333;(1H-Indol-3-ylmethyl)-carbamic acid tert-butyl ester;(1H-Indol-3-ylmethyl)-carbamic acid tert-butyl ester

Suppliers and Price of tert-Butyl ((1H-indol-3-yl)methyl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(1H-Indol-3-ylmethyl)carbamicacidtert-butylester
100mg
$ 65.00

TRC
(1H-Indol-3-ylmethyl)carbamicacidtert-butylester
250mg
$ 140.00

Matrix Scientific
(1H-Indol-3-ylmethyl)carbamic acidtert-butyl ester 95+%
5g
$ 325.00

Matrix Scientific
(1H-Indol-3-ylmethyl)carbamic acidtert-butyl ester 95+%
1g
$ 108.00

Matrix Scientific
(1H-Indol-3-ylmethyl)carbamic acidtert-butyl ester 95+%
10g
$ 598.00

Crysdot
tert-Butyl((1H-indol-3-yl)methyl)carbamate 95+%
10g
$ 354.00

Crysdot
tert-Butyl((1H-indol-3-yl)methyl)carbamate 95+%
1g
$ 72.00

Crysdot
tert-Butyl((1H-indol-3-yl)methyl)carbamate 95+%
5g
$ 213.00

Chemenu
tert-Butyl((1H-indol-3-yl)methyl)carbamate 95%
5g
$ 201.00

Chemenu
tert-Butyl((1H-indol-3-yl)methyl)carbamate 95%
10g
$ 334.00

Total 22 raw suppliers

Chemical Property of tert-Butyl ((1H-indol-3-yl)methyl)carbamate

Chemical Property:

Melting Point:102-103 °C
Boiling Point:437.0±28.0 °C(Predicted)
PKA:12.86±0.46(Predicted)
PSA：54.12000
Density:1.155±0.06 g/cm3(Predicted)
LogP:3.58350
Storage Temp.:2-8°C
XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:246.136827821
Heavy Atom Count:18
Complexity:299

Purity/Quality:

97% ^*data from raw suppliers

(1H-Indol-3-ylmethyl)carbamicacidtert-butylester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NCC1=CNC2=CC=CC=C21
Uses (1H-Indol-3-ylmethyl)carbamic acid tert-butyl ester

Technology Process of tert-Butyl ((1H-indol-3-yl)methyl)carbamate

There total 3 articles about tert-Butyl ((1H-indol-3-yl)methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 22259-53-6
3-aminomethylindole

: 60524-00-7
tert-butyl ((1H-indol-3-yl)methyl)carbamate

Guidance literature:: With potassium carbonate; In water; acetone; at 0 - 20 ℃;
DOI:10.1021/acs.jmedchem.8b01936

Reference yield:

: 5457-28-3
3-cyano-1H-indole

: 60524-00-7
tert-butyl ((1H-indol-3-yl)methyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran; 1,4-dioxane / 1 h / 0 °C / Reflux

2: triethylamine; dmap / tetrahydrofuran; dichloromethane / 2 h / 20 °C

With dmap; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;