PCI 34051

Base Information

Chemical Name:PCI 34051
CAS No.:950762-95-5
Molecular Formula:C₁₇H₁₆N₂O₃
Molecular Weight:296.326
Hs Code.:
Mol file:950762-95-5.mol

Synonyms:PCI-34051;PCI 34051;PCI-34051;PCI 34051;N-hydroxy-1-(4-Methoxybenzyl)-1H-indole-6-carboxaMide;1-(4-methoxybenzyl)-N-hydroxy-1H-indole-6-carboxamide;N-hydroxy-1-[(4-methoxyphenyl)methyl]indole-6-carboxamide;N-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide;1H-Indole-6-carboxamide, N-hydroxy-1-[(4-methoxyphenyl)methyl]-

Suppliers and Price of PCI 34051

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
PCI-34051
10mg
$ 460.00

Usbiological
PCI 34051
10mg
$ 438.00

TRC
PCI-34051
100mg
$ 1155.00

Tocris
PCI34051 ≥98%(HPLC)
10
$ 116.00

Tocris
PCI34051 ≥98%(HPLC)
50
$ 471.00

Medical Isotopes, Inc.
PCI-34051
10 mg
$ 650.00

DC Chemicals
PCI-34051 >98%
1 g
$ 1600.00

DC Chemicals
PCI-34051 >98%
250 mg
$ 800.00

Crysdot
PCI-34051 98+%
50mg
$ 491.00

Crysdot
PCI-34051 98+%
100mg
$ 893.00

Total 30 raw suppliers

Chemical Property of PCI 34051

Chemical Property:

PKA:9.16±0.30(Predicted)
PSA：63.49000
Density:1.25
LogP:3.20810
Storage Temp.:2-8°C
Solubility.:insoluble in H2O; insoluble in EtOH; ≥14.8 mg/mL in DMSO

Purity/Quality:

99%, ^*data from raw suppliers

PCI-34051 ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22-36
Safety Statements: 26

MSDS Files:: SDS file from LookChem

Useful:

Uses PCI-34051 is a potent, histone deacetylase 8 (HDAC8)-specific inhibitor. PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias. PCI-34051 did not affect other hematopoietic or solid tumor lines. PCI-34051 treatment has been shown to significantly reduce cholesterol accumulation in Niemann-Pick type C1 gene mutated human fibroblast.

Technology Process of PCI 34051

There total 2 articles about PCI 34051 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 950763-29-8
PCI-34051

: 950762-95-5
N-hydroxy-1-(4-methoxybenzyl)-1H-indole-6-carboxamide

Guidance literature:: PCI-34051; With sodium hydroxide; hydroxylamine; In tetrahydrofuran; methanol; water; at 20 ℃; for 1h;

With hydrogenchloride; In water; pH=7 - 8;

Reference yield:

: 50820-65-0
indole-6-carboxylic acid methyl ester

: 2746-25-0
p-Methoxybenzyl bromide

: 950762-95-5
N-hydroxy-1-(4-methoxybenzyl)-1H-indole-6-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 3.5 h / 20 °C

2.1: sodium hydroxide; hydroxylamine / tetrahydrofuran; methanol; water / 1 h / 20 °C

2.2: pH 7 - 8

With sodium hydroxide; hydroxylamine; sodium hydride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;