PI3K/HDAC Inhibitor

Base Information

• Chemical Name: PI3K/HDAC Inhibitor
• CAS No.: 1339928-25-4
• Molecular Formula: C23H24N8O4S
• Molecular Weight: 508.55
• Mol file: 1339928-25-4.mol

Synonyms:PI3K/HDAC Inhibitor centn;CUDC-907;,C23H24N8O4S,CUDC907,CUDC 907;

Chemical Property of PI3K/HDAC Inhibitor

Chemical Property:

• PKA: 7.77±0.10(Predicted)
• PSA: 170.45000
• Density: 1.445±0.06 g/cm3(Predicted)
• LogP: 2.78370
• Solubility.: ≥25.45 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH

Purity/Quality:

98%,99%, ^*data from raw suppliers

CUDC-907 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: CUDC-907 is a dual PI3K and HDAC inhibitor. Studies have shown CUDC-907 is able to enhance antitumor activity when combined with standard of care agents in multiple myeloma and B cell lymphoma xenogra ft models. CUDC-907 is a dual PI3K and HDAC inhibitor. Studies have shown CUDC-907 is able to enhance antitumor activity when combined with standard of care agents in multiple myeloma and B cell lymphoma xenograft models.

Technology Process of PI3K/HDAC Inhibitor

There total 22 articles about PI3K/HDAC Inhibitor which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl-2-(((2-(6-methoxypyridin-3-yl)-4-morpholinothieno [3,2-d]pyrimidin-6-yl) methyl) (methyl)amino)pyrimidine-5-carboxylate → CUDC-907 (1339928-25-4)

Guidance literature:

With hydroxylamine; In methanol; dichloromethane; at 20 ℃; for 14h; Sealed tube;

Reference yield: 76.0%

methyl 2-(N-((2-(6-methoxypyridin-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)-N-methylamino)pyrimidine-5-carboxylate → CUDC-907 (1339928-25-4)

Guidance literature:

With hydroxylamine; In methanol; dichloromethane; at 20 ℃; for 5h; Sealed tube;

Reference yield:

2-methoxy-pyridine-5-boronic acid (163105-89-3,600726-67-8) → CUDC-907 (1339928-25-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride / water; 1,4-dioxane / 15 h / 108 °C / Inert atmosphere

2: hydroxylamine / dichloromethane; methanol / 5 h / 20 °C / Sealed tube

With bis-triphenylphosphine-palladium(II) chloride; hydroxylamine; sodium hydrogencarbonate; In 1,4-dioxane; methanol; dichloromethane; water;

upstream raw materials:

2-methoxy-pyridine-5-boronic acid

ethyl 2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

ethyl 2-oxo-1,2-dihydropyrimidine-5-carboxylate

ethyl 2-chloropyrimidine-5-carboxylate

Refernces

• 1、 -. "COMBINATION THERAPY WITH A PHOSPHOINOSITIDE 3-KINASE INHIBITOR WITH A ZINC BINDING MOIETY". Page/Page column 25; 33; 34; 35. . Retrieved 2018/05/24.