Bis(2-amino-4-methylphenyl) disulfide

Base Information

• Chemical Name: Bis(2-amino-4-methylphenyl) disulfide
• CAS No.: 22261-57-0
• Molecular Formula: C14H16N2S2
• Molecular Weight: 276.42
• Hs Code.: 2930909090
• Mol file: 22261-57-0.mol

Synonyms:2,2'-Diamino-4,4'-dimethyl-diphenyldisulfid;Bis-<2-amino-4-methyl-phenyl>-disulfid;5,5'-dimethyl-2,2'-disulfanediyl-bis-aniline;

Chemical Property of Bis(2-amino-4-methylphenyl) disulfide

Chemical Property:

• PSA: 102.64000
• LogP: 5.42960

Purity/Quality:

≥95% ^*data from raw suppliers

Bis(2-amino-4-methylphenyl)disulfide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Bis(2-amino-4-methylphenyl) disulfide

There total 3 articles about Bis(2-amino-4-methylphenyl) disulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-4-methyl-benzenethiol (31183-81-0) → bis(2-amino-4-methylphenyl) disulfide (22261-57-0)

Guidance literature:

With hydrogenchloride; iron(III) chloride;

DOI:10.1021/jm00285a022

Reference yield:

2,5-dimethylbenzothiazole (95-26-1) → bis(2-amino-4-methylphenyl) disulfide (22261-57-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; water / ethylene glycol / Inert atmosphere; Reflux

2: sodium iodide; dihydrogen peroxide / ethyl acetate; water / 0.5 h / 0 °C

With water; dihydrogen peroxide; sodium iodide; sodium hydroxide; In water; ethylene glycol; ethyl acetate;

DOI:10.1021/jacs.5b02537

Reference yield:

2-chloro-5-methylaniline (95-81-8) → bis(2-amino-4-methylphenyl) disulfide (22261-57-0)

Guidance literature:

Multistep reaction; (i) aq. Na₂S, (ii) aq. H₂O₂;

DOI:10.1021/jm00301a008

upstream raw materials:

2-chloro-5-methylaniline

2-amino-4-methyl-benzenethiol

2,5-dimethylbenzothiazole

Downstream raw materials:

α-<<4-methyl-2-(1H-pyrrol-1-yl)phenyl>thio>phenylacetic acid ethyl ester

α-<<4-methyl-2-(1H-pyrrol-1-yl)phenyl>thio>phenylacetic acid

9-Methyl-5-phenyl-6-thia-10b-aza-benzo[e]azulen-4-one

4-Methyl-2-pyrrol-1-yl-benzenethiol

Refernces

• 1、 Palmer,Trigg,Warrington. "Benzothiazolines as antituberculous agents.". . p. 248 - 251. Retrieved 2007/10/04.