4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester

Base Information

Chemical Name:4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester
CAS No.:1144035-53-9
Molecular Formula:C22H21Cl2N3O5
Molecular Weight:478.332
Hs Code.:
Mol file:1144035-53-9.mol

Synonyms:PF-8380

Suppliers and Price of 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
PF 8380
10mg
$ 480.00

Usbiological
PF-8380
100mg
$ 1805.00

TRC
PF8380
100mg
$ 1260.00

Tocris
PF8380 ≥97%(HPLC)
25
$ 462.00

Tocris
PF8380 ≥97%(HPLC)
5
$ 122.00

Sigma-Aldrich
PF-8380 ≥98% (HPLC)
5mg
$ 104.00

Sigma-Aldrich
Autotaxin Inhibitor III, PF-8380
10mg
$ 211.00

Sigma-Aldrich
PF-8380 ≥98% (HPLC)
25mg
$ 400.00

Medical Isotopes, Inc.
PF8380
10 mg
$ 650.00

Matrix Scientific
3,5-Dichlorobenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo-[d]oxazol-6-yl)propyl)piperazine-1-carboxylate 95+%
250mg
$ 742.00

Total 52 raw suppliers

Chemical Property of 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester

Chemical Property:

PKA:8.74±0.70(Predicted)
PSA：95.85000
Density:1.419
LogP:3.83090
Storage Temp.:?20°C
Solubility.:DMSO: soluble5mg/mL, clear (warmed)

Purity/Quality:

99%, ^*data from raw suppliers

PF 8380 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses PF8380 is a novel autotaxin inhibitor which reduces lysophosphatidic acid levels in plasma and at the site of inflammation. PF-8380 has been used in biological assays. It has also been used to estimate the role of intestinally-derived lysophosphatidic acid in dyslipidemia and atherosclerosis.

Technology Process of 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester

There total 8 articles about 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic acid 3,5-dichlorobenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: C₁₂H₁₄Cl₂N₂O₂*C₂HF₃O₂

: 132383-36-9
6-(3-chloropropanoyl)-2,3-dihydro-1,3-benzoxazol-2-one

: 1144035-53-9
3,5-dichlorobenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)propyl)piperazine-1-carboxylate

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; Inert atmosphere;
DOI:10.1021/acsmedchemlett.7b00312

Reference yield:

: 60211-57-6
3,5-dichlorobenzyl alcohol

: C₁₅H₁₆ClN₃O₄

: 1144035-53-9
3,5-dichlorobenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)propyl)piperazine-1-carboxylate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;
DOI:10.1124/jpet.110.165845

Reference yield:

: 59-49-4
2-Benzoxazolinone

: 1144035-53-9
3,5-dichlorobenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)propyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: aluminum (III) chloride / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

1.2: 3 h / 80 °C / Inert atmosphere

2.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / Inert atmosphere

With aluminum (III) chloride; sodium hydrogencarbonate; In N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.7b00312