Ethyl 3-(3-fluoro-4-hydroxyphenyl)-2-methylpropanoate

Base Information

• Chemical Name: Ethyl 3-(3-fluoro-4-hydroxyphenyl)-2-methylpropanoate
• CAS No.: 1234848-20-4
• Molecular Formula: C12H15FO3
• Molecular Weight: 226.248
• Mol file: 1234848-20-4.mol

Synonyms:ETHYL 3-(3-FLUORO-4-HYDROXYPHENYL)-2-METHYLPROPANOATE;Benzenepropanoic acid, 3-fluoro-4-hydroxy-α-methyl-, ethyl ester

Chemical Property of Ethyl 3-(3-fluoro-4-hydroxyphenyl)-2-methylpropanoate

Chemical Property:

• Boiling Point: 302.2±27.0 °C(Predicted)
• PKA: 8.67±0.20(Predicted)
• PSA: 46.53000
• Density: 1.161±0.06 g/cm3(Predicted)
• LogP: 2.27300
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 3-(3-fluoro-4-hydroxyphenyl)-2-methylpropanoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 3-(3-fluoro-4-hydroxyphenyl)-2-methylpropanoate

There total 4 articles about Ethyl 3-(3-fluoro-4-hydroxyphenyl)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-(3-fluoro-4-methoxyphenyl)-2-methylpropionic acid ethyl ester (1609289-59-9) → 3-(3-fluoro-4-hydroxyphenyl)-2-methylpropionic acid methyl ester (1234848-20-4)

Guidance literature:

With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 3h;

Reference yield:

(E)-3-(3-fluoro-4-methoxyphenyl)-2-methylacrylic acid ethyl ester (1609289-58-8) → 3-(3-fluoro-4-hydroxyphenyl)-2-methylpropionic acid methyl ester (1234848-20-4)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 12 h / 20 °C

2: boron tribromide / dichloromethane / 3 h / -78 - 20 °C

With palladium 10% on activated carbon; hydrogen; boron tribromide; In ethanol; dichloromethane;

Reference yield:

3-fluoro-p-anisaldehyde (351-54-2) → 3-(3-fluoro-4-hydroxyphenyl)-2-methylpropionic acid methyl ester (1234848-20-4)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 3 h / 0 - 20 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 12 h / 20 °C

3: boron tribromide / dichloromethane / 3 h / -78 - 20 °C

With palladium 10% on activated carbon; hydrogen; boron tribromide; In tetrahydrofuran; ethanol; dichloromethane;

upstream raw materials:

(E)-3-(3-fluoro-4-methoxyphenyl)-2-methylacrylic acid ethyl ester

3-fluoro-p-anisaldehyde

3-(3-fluoro-4-methoxyphenyl)-2-methylpropionic acid ethyl ester

(carbethoxyethylidene)triphenylphosphorane

Refernces